Sentences with phrase «initiated tumor development»

As few as 100 PC3 cells initiated tumor development in one of the eight injections and at ≥ 10,000 cells most of the injections of either PC3 or PC3 - GFP cells developed tumors (Table 1).

Sometimes oncogenes manage to initiate tumor development in the presence of p53, but, even then, the tumor suppressor doesn't give up and focuses its efforts instead on limiting the tumor's ability to invade and metastasize.

PC3 holoclones, but not paraclones or meroclones, contain stem - like cancer cells that could initiate tumor development and sustain serial tumor transplantation.

The only paraclone of which we managed to harvest 1,000 cells did not initiate tumor development (Table 1).

In contrast, meroclones and paraclones can not be continuously propagated and fail to initiate tumor development.

Not exact matches

And in at least a few lab - reared fish, UV can initiate the development of melanoma (especially among hybrids which inherit a tumor - promoting gene from one parent but no accompanying tumor - suppressor gene from the other).

«This development has the potential to enable earlier detection of solid tumors through a simple blood draw by substantially improving our ability to detect very low quantities of circulating DNA derived from tumor cells,» says corresponding author Hunter Underhill, M.D., Ph.D., who initiated the research while in the lab of senior author Jay Shendure, M.D., Ph.D., a professor in genome sciences at the University of Washington.

The scientists discovered that TRPV1, once activated by the EGFR, initiates a direct negative feedback on the EGFR, dampening the latter to reduce the risk of unwanted growth and intestinal tumor development.

He has over 250 publications in the areas of signaling by growth factor receptors and oncogenes in breast tumor cells, development of targeted therapies and biomarkers of drug action and resistance, and investigator - initiated clinical trials in breast cancer.

As shown in Table 1, both PC3 and PC3 - GFP cells initiated cell number — dependent tumor development in NOD / SCID mice.

Three holoclones (i.e., P3C4, P1E2, and P1H8), harvested around 6 to 8 weeks after plating, when injected at 1,000 or 10,000 cells, all initiated 80 % to 100 % tumor development in NOD / SCID mice in 47 to 75 days (Table 1; Fig. 3A).