Sentences with phrase «initiation of»

Rats (150 - 160 g at initiation of feeding protocol) are allowed ad libitum access to the Lieber - DeCarli ethanol diet or pair - fed a control diet, as previously described (1,3).

We have found that the initiation of pancreatic cancer does not follow the classic paradigm seen in colon cancer where loss of a tumor suppressor gene initiates tumorigenesis and then acquisition of an oncogene promotes tumor formation.

SEATTLE, WA and DURHAM, NC — The HIV Vaccine Trials Network (HVTN) and the HIV Prevention Trials Network (HPTN) today announced the initiation of HVTN 704 / HPTN 085, also known as Antibody Mediated Prevention (AMP) or the AMP Study, a Phase 2b clinical trial to evaluate the safety and efficacy of VRC01, a broadly neutralizing monoclonal antibody (bnAb).

In 2017, he took up the position of Assistant Professor at the Fox Chase Cancer Center in Philadelphia, heading his own laboratory, which focuses on how tissue and organ degeneration, regeneration defects, and decline in regenerative capacity affect the initiation of cancer.

These goals may include career options with companies, initiation of collaborations, and development of better product solutions for labs.

This may help explain some of the changes that are not explained by the orbital curves in the other thread, especially the initiation of warming and cooling since the GCR effects can be much more powerful (partly forcing as postulated in the paper, but also amplification of the weaker orbital forcing).

Smith, K. L. & Kushner, P. J. Linear interference and the initiation of extratropical stratosphere — troposphere interactions.

In addition to Davis and Clark, other coauthors on the study, entitled «CRLX101 nanoparticles localize in human tumors and not in adjacent, nonneoplastic tissue after intravenous dosing,» include Devin Wiley (MS» 11, PhD» 13) and Jonathan Zuckerman (PhD» 12); Paul Webster of the Oak Crest Institute of Science; Joseph Chao and James Lin at City of Hope; and Yun Yen of Taipei Medical University, who was at City of Hope and a visitor in the Davis lab at the initiation of the clinical trial.

Song, S.Y., Gannon, M., Washington, M.K., Scogins, C.R., Meszoely, I.M., GOLDENRING, J.R., Marino, C.R., Sandgren, E.P., Coffey, R.J., Jr., Wright, C.V.E. and Leach, S.D. Expansion of pdx1 - expressing pancreatic epithelium and initiation of islet neogenesis in transgenic mice overexpressing TGF.

Despite more than 30 years passing between the fall of the Khmer Rouge regime and the initiation of skeletal analysis in Cambodia, these data are important reminders for current and future generations.

Correlation analysis between scores in negative emotionality and history of marijuana abuse showed a negative correlation between age of initiation of marijuana abuse and negative emotionality scores (r = 0.58, P = 0.003) such that the younger the initiation, the higher the scores.

The Sheffield team led by Dr Kurt De Vos and Dr Andy Grierson investigated the role of the C9orf72 protein in nerve cells and found it regulates the initiation of a vital process called «autophagy», which helps the cell to dispose of damaged proteins and cell parts, and recycles cell nutrients.

Dr De Vos said: «Our study provides compelling evidence that the C9orf72 protein is required for the initiation of autophagy, a pathway essential for the survival of nerve cells.

At initiation of elongation, these integrated regions appeared adherent to the Aclar membranes and displayed no motion with agitation of the expansion chamber.

Researchers at the University of California, Riverside have found that thirdhand - smoke (THS) exposure has a significant effect on health as early as one month after initiation of exposure — an effect that worsens with time.

The association between negative emotionality and age of initiation of marijuana abuse is consistent with prior findings of worse outcomes with earlier initiation of marijuana abuse (77).

By 2006, the ACC / AHA had downgraded its recommendation regarding the preoperative initiation of beta - blockers and in 2009 the recommendation was downgraded further.

A new study by researchers at Columbia University's Mailman School of Public Health and the City University of New York reports that cannabis use was associated with an increased initiation of cigarette smoking among non-cigarette smokers.

The combination of PrEP and prompt initiation of ART for infected individuals offers a promising blueprint to bring about an end to the HIV / AIDS pandemic, the authors write.

In addition, three randomized controlled studies in 2005 and 2006 cast further doubt on earlier findings: none of them observed any difference in postoperative outcomes with preoperative initiation of Beta - blockers versus placebo.

There was an average total delay of about six months between the first symptom and the initiation of treatment.

Initiation of their photocycle was triggered with a precisely synchronised blue laser pulse.

While the last decade has seen many potential new agents for hepatocellular carcinoma fail in clinical trials, phase I and II data from early regorafenib trials were promising, and led to the initiation of this international, multi-center phase III trial.

Just 24 hours later, much more fluorescing cells were back, indicating the initiation of cell division activity of surviving cells within the ventricle.

The continued fall in transmission rates is thought to be due to a combination of factors including earlier initiation of antenatal combination antiretroviral therapy (cART) and an increase in the number of women already on cART when they conceive.

For the paper, «Transmission dynamics and control of Ebola Virus Disease (EVD) outbreak in Nigeria, July - September, 2014,» published today in Eurosurveillance, researchers used epidemic modeling to project the size of the outbreak in Nigeria if control interventions had been implemented during various time periods after the initial case and estimated how many cases had thus been prevented by early initiation of interventions.

The virus was most likely blocking the initiation of cellular translation.

Deploying a point - of - care test for infant diagnosis of HIV using a portable, battery - operated device may result in more timely initiation of drug therapy, decreasing the number of children who are diagnosed with HIV weeks or months after birth and never receive treatment.

«Decisions about initiation of active treatment in extremely premature babies are difficult and emotionally charged,» Carlo said.

«This cutoff [6 ng / L] enables a rapid triage that excludes AMI and a faster initiation of evidence - based treatment for patients diagnosed as having AMI,» the authors write.

«Clearly there is little consensus about the appropriate policy for treating infants born at low gestational ages, and yet hospital practices regarding the initiation of active intervention have a dramatic influence on rates of survival and survival without impairment,» wrote Neil Marlow, D.M., University College London, in an NEJM editorial that accompanied the research paper.

While the observed differences of the individual steps were mostly modest, mathematical modeling suggested that even small delays in the trafficking of these immune cells will lead to reduced initiation of a WNV - specific antibody - response during the early stages after infection.

Earthquake early warning systems detect the initiation of an earthquake and issue warning alerts of possible forthcoming ground shaking.

Previous studies have suggested that having more critical care physicians providing care, earlier initiation of antibiotics, more targeted delivery of intravenous fluids and more gentle mechanical ventilation may improve outcomes of patients with severe sepsis.

The feedback, which couples the initiation of endocytic waves by clathrin to cortical actin waves is analogous to a group of people walking on a wobbly bridge.

While early initiation of ART did result in a delay in the time to viral rebound (the time it takes for virus replication to be observed in the blood following cessation of ART) as compared with later treatment, the inability to eradicate the viral reservoir with very early initiation of ART suggests that additional strategies will be needed to cure HIV infection.

There was also a more than 4-fold increase in the yearly rate of improvement in the proportion of patients with door - to - needle times of 60 minutes or less after initiation of the intervention.

«Taken together, our data suggest that extremely early initiation of ART, extended ART duration, and probably additional interventions that activate the viral reservoir will be required for HIV - 1 eradication.»

It also provides valuable information that may assist researchers in the development of genetic tests based on next generation sequencing, and in the initiation of large intervention trials to assess the efficacy of orphan drugs.

The ability to deliver XL184 and PDT almost simultaneously allowed the two therapeutics to be «at the right place at the right time» to cut off the rapid initiation of escape signaling that usually follows PDT.

«The concept of timing of initiation of an intervention is likely applicable to most preventive approaches to cardiovascular disease in women.»

The money supports the initiation of the Geo - referenced Infrastructure and Demographic Data for Development (GRID3) program, together with UNFPA and Columbia University, aimed at supporting governments in low income countries to construct and use spatially detailed data on infrastructure and population.

«We show a direct link between Kras mutations and the inflammatory environment that drive the initiation of pancreatic cancer,» Dr. Storz says.

Studies of skin organogenesis have presupposed that a periodic molecular prepattern is responsible for the initiation of a periodic pattern of hair or feathers.

Relevant to authorship are several issues: the initiation of the project («my idea»), innovative contributions («let's do it this way»), time in the lab («I did all of the work»), time spent writing («I wrote most of the article»), the tedium of the work, connections with the publisher («I know the journal editor»), seniority in the department, and specific needs, such as those in this case.

Data were separated into Phase I (the time between study entry and a clinician's determination that levodopa therapy was required) and Phase II (the time between initiation of levodopa therapy and the conclusion of follow - up).

After the initiation of an opioid, the researchers found a downward trend in the prevalence of both antipsychotics and benzodiazepines, with the prevalence of antipsychotics reducing more.

They focused on the initiation of corrosion — the point at which the metal surface begins to dissolve.

«Our study examined the association between urinary BPA levels and prostate cancer and assessed the effects of BPA on the initiation of centrosome abnormalities as an underlying mechanism promoting prostate cancer formation.»

The data demonstrate the role of myocardial Gq in the initiation of myocardial hypertrophy and indicate a possible strategy for preventing pathophysiological signaling by simultaneously blocking multiple receptors coupled to Gq.