The phrase
"initiation site" refers to a specific location or point where a process or activity begins or starts.
Full definition
The mechanism of action for translation enhancing elements is still obscure, particularly in the case of internal
ribosomal initiation sites.
In the atmosphere, aerosols serve as
initiation sites for the condensation or deposition of water vapour.
«The broader implications of our work,» the researchers say, «are that even subclinical insults to the stomach that occur in daily life (damage from grinding of food, ingestion of alcohol, taking an aspirin) can potentially attract H. pylori and not only slow repair of any existing damage, but maybe also provide
an initiation site that can start the pathogenic sequence of more severe stomach diseases caused by H. pylori.»
Roughly 20 percent of the translation enhancing elements functioned as internal ribosomal
initiation sites, again turning up primarily in non-coding genomic regions.
However if the ribosome skipped the hairpin and recognized the sequence on the other side of the hairpin independently and translated it, that's an indication that the sequence is functioning as an internal ribosomal
initiation site.»
In a second scheme, transcription activator - like effector nucleases (TALENs) were targeted to sequences near the translation -
initiation site of CCHa2 - R to create a frame - shift mutation in the CCHa2 - R coding region [24].