But the scientists noticed something odd when they ran control experiments in which
they injected the hydrogel without added cells: Some of the animals» hearts still showed improvement compared with untreated animals.
They found that when arthritis was more severe, the locally
injected hydrogel degraded more rapidly corresponding to increased drug release.
Not exact matches
The study most often used to argue that
hydrogel is dangerous found it was toxic only when
injected directly into a rat's vein or body cavity.
When
hydrogel was
injected just below a rat's skin, it wasn't toxic.
The
hydrogel would be
injected in liquid form and would polymerize in the transplant site, creating a flexible gel that would conform to bodily structures to improve both blood vessel connections and tissue integration.
The chitosan and polyvinyl alcohol composite
hydrogel containing hTGFβ - 1 gene modified BMSCs was
injected into rabbits with defective articular cartilage.
Some experimental heart attack treatments require surgery to open up the chest, but the two
hydrogel materials already in clinical trials are
injected into the damaged tissue through a long catheter inserted through the skin — eliminating the need for open - chest surgery.
In experiments carried out in the lab, BWH bioengineers have developed a
hydrogel — a soft, flexible material that can be loaded with arthritis drugs and
injected locally into an inflamed joint.
Scientists worldwide have tried to
inject chemical
hydrogels into living cells to study them, but usually the cells become sick, likely due to toxicity from the chemicals.
Eduardo Mendizábal Mijares, professor at the Department of Chemistry, in the University of Guadalajara, said «we used nano -
hydrogels loaded with drugs and
injected them into the patient.
The
hydrogel - drug combo is
injected under the skin after transplant surgery.
Two days after the nanosponge -
hydrogel was
injected underneath the skin of a mouse, nearly 80 percent of the nanosponges were still found at the injection site.
After the filaments are
injected into the body, the resulting
hydrogel network functions as a drug depot that slowly degrades by breaking down into spherical nanomaterials called micelles, which are programmed to travel to specific targets.
«After
injecting the nanosponge -
hydrogel at the infected spot, we observed that it absorbed the toxins secreted by the bacteria and prevented further damage to the local blood, skin and muscle tissues,» said Zhang.
To investigate this hypothesis, the authors
injected a collagen
hydrogel into the kidneys of mice with ischemia / reperfusion damage and assessed the consequences at four weeks.
A team of MIT researchers has developed a new, self - healing
hydrogel that doesn't require surgical implantation, but can be
injected using a syringe.