Kilian said his team's synthetic microenvironment lies somewhere in the middle of two extremes in the field of modeling biology: the hard plastic plate, and expensive mouse avatars that are created by
injecting human tumor cells into mice.
Not exact matches
In addition, they
injected mice with
human cancer
cells and found that the
tumors grown in mice could be inhibited with PD173074.
Shah and his team loaded the herpes virus into
human MSCs and
injected the
cells into glioblastoma
tumors developed in mice.
Compared to a control (left), epalrestat treatment (right) reduces the number of metastatic
tumors (arrowheads) in the lungs of mice
injected with
human basal - like breast cancer
cells.
In experiments involving mice
injected with
human GBM
cells, the scientists also demonstrated that if either PTEN or DAXX were eliminated, then
tumor growth occurred.
In this study, the researchers tested the effects of Olaparib on the
tumors formed by
human breast cancer
cells injected into mice.
They then tested the behavior of
human tumor cells with and without HOXA5 by
injecting those
cells into the mammary fat pad of mice.
IHC - P mouse
tumor tissue (from lung) with
human cell line
injected, some muscle tissue attached as well sees high background for
human cellswith priamry Ab as well as isotype ctrl, but also for muscle (does not contain any EGF) Ab: 1 ug /...
The researchers then
injected AAV2 into
human breast cancer
cell line - derived
tumors in mice without functioning immune systems.
This finding was reinforced by an animal study, in which tocotrienol inhibited
tumor growth in mice that had been
injected with
human liver cancer
cells.