Sentences with phrase «injured axons»
The focus of my laboratory is on exploring novel approaches for solving the fundamental problem of the failure of CNS projection neurons to regenerate injured axons and developing translational approaches for treating optic neuropathies (e.g., glaucoma) and other types of CNS injuries.
https://www.brightfocus.org/
The current focus of Dr. Trakhtenberg's research is on solving the fundamental problem of the failure of CNS projection neurons to regenerate injured axons and developing translational approaches for treating optic neuropathies (eg, glaucoma) and other types of CNS injuries.
They found that when Axed function was blocked, injured axons not only maintained their integrity but remained capable of transmitting signals within the brain's complex circuitry for weeks.
«This clearly refuted the assumption that getting rid of scars would permit spontaneous regeneration of injured axons,» Sofroniew said.
The method demonstrates that injured axons can be preserved for at least 10 times longer when their communication with neighbors is blocked.
Studying mice, the researchers found that a gene called Phr1 plays a major role in governing the self - destruction of injured axons.
But the current technology — diffusion MRI, also called diffusion tensor imaging (DTI)-- didn't allow him to see injured axons that might explain the problems of TBI patients.
«Whether human PSR has the capacity to repair injured axons is still unknown,» he said.
«This implies that axons talk to each other while they are dying, and an injured axon can coax an uninjured neighbor to die, too.»
Not exact matches
«If we want to regenerate an injured system,» Fox explains, «we have to understand how all these axons form connections in the first place.
Sheng and his research fellow Bing Zhou, the first author of the study, initially found that when mature mouse axons are severed, nearby mitochondria are damaged and become unable to provide sufficient ATP to support injured nerve regeneration.
«Our study shows that Ind - Cl can remyelinate axons which have gotten injured not just in MS but also traumatic brain injury and spinal cord injury.»
Promoting directional axon growth from neural progenitors grafted into the injured spinal cord.
These and other differences between hGDAsBMP and undifferentiated hGPCs and hGDAsCNTF, such as the marked differences in expression of axon growth inhibitory CSPGs and the expression of GDNF, may all contribute to creating a particularly effective cell type for promoting functional recovery in the traumatically injured adult central nervous system.
When retinal ganglion cell (RGC) axons are injured, before completely degenerating, they exhibit a phase during which their internal «skeletal» structure (normally consisting of a highly organized arrangement of fibers) becomes disorganized.
This occurs in part because the intrinsic growth capacity of retinal ganglion cells rapidly declines after birth, and injured central nervous system axons fail to regenerate.