In 2008, he joined the group of Caetano Reis e Sousa at the Cancer Research UK (CRUK) London Research Institute and later joined the Francis Crick Institute, where he was awarded Marie Curie and EMBO long - term postdoctoral fellowships to
investigate innate immune receptors and signaling pathways that trigger dendritic cell activation and drive T - cell responses against viruses or tumors.
Metabolic changes triggered
by innate immune receptors have become a particular focus for researchers interested in immunity and inflammation.
This live cell assay features a cell line expressing
the innate immune receptor, Toll - like receptor - 2 (TLR2).
Recent research has identified
the innate immune receptor genes TREM2 and CD33 / SIGLEC3 as particularly relevant to Alzheimer's disease.