«In general, the lower the temperature, it seems the lower
the innate immune response to viruses,» noted Iwasaki.
Not exact matches
«The first line of defense of the
immune system, the
innate immune response, is not acting quickly enough
to clear the
virus,» says co-lead author Gülsah Gabriel, a virologist at the Heinrich Pette Institute, Leibniz Institute for Experimental Virology in Hamburg, Germany.
The UNC research team, led by Lemon and Jason Whitmire, Ph.D., Associate Professor in UNC's Department of Genetics, is now poised
to investigate the complicated interplay of nonspecific «
innate» and specific «adaptive»
immune responses that ultimately control the infection and eliminate HAV from the host — processes that are not well understood for any of the five human hepatitis
viruses.
«We're going
to introduce additional mutations
to sensitize the
virus even more
to the
innate immune response and prevent the infection from spreading,» said Diamond, who also is a professor of molecular microbiology, and of pathology and immunology.
When researchers infected these ERV - depleted cells with the vaccinia
virus (which may be related
to smallpox), they had a much weaker
innate immune response than unedited normal cells, the team reports online today in Science.
In 2008, he joined the group of Caetano Reis e Sousa at the Cancer Research UK (CRUK) London Research Institute and later joined the Francis Crick Institute, where he was awarded Marie Curie and EMBO long - term postdoctoral fellowships
to investigate
innate immune receptors and signaling pathways that trigger dendritic cell activation and drive T - cell
responses against
viruses or tumors.
In addition, the strain isolated from lions and hyenas during the 1993/1994 epidemic had rare mutations in two viral proteins: the CDV - H protein, which binds
to the host cell receptor (called SLAM CD 150) and therefore plays an important role
to facilitate viral entry into host cells, and the CDV - V protein, which enables the
virus to manipulate the
innate immune response of the host.
Cytokine milieu of atopic dermatitis skin subverts the
innate immune response to vaccinia
virus.