Sentences with phrase «innate immune signaling»

Finally, we are delineating the innate immune signaling pathways governing the antiviral restriction activities of the protein SAMHD1.

After working on innate immune signaling at a Biotech startup company she studied mechanisms of signaling specificity as a postdoc in Dr. Alexander Hoffmann's laboratory at the University of California, San Diego before joining the Molecular Cell editorial team in 2013.

Cooke said the team is developing methods to manipulate innate immune signaling of ROS to maximize the production of iPSCs and better direct their differentiation.

Their activation of innate immune signaling caused epigenetic changes that were absolutely necessary for the transformation of somatic cells into iPSCs,» explained Cooke, who holds the Joseph C. «Rusty» Walter and Carole Walter Looke Presidential Distinguished Chair in Cardiovascular Disease Research.

Innate immune signaling is known to stimulate ROS production, which participates in cell defense.

The idea to check the role of the bacterium associated with innate immune signaling in chemotherapy resistance was linked to earlier work done by this researcher team.

In the current study in Cell, they researched whether bacterium - mediated innate immune signaling regulates chemotherapy resistance in colon cancer.

That gave us the inspiration to look further at bacterium associated with innate immune signaling.

Gram - negative bacteria produce molecules called lipopolysaccharides (LPS) that are potent activators of innate immune signaling.

This finding reveals unexpected roles for the microbiome and innate immune signalling in the pathogenesis of a cerebrovascular disease, as well as suggesting novel strategies for its treatment.

Not exact matches

Mice deficient in critical innate immune functions such as Toll - like receptor signaling or oxidative burst production spontaneously produce high - titer serum antibodies against their commensal microbiota.

These receptors detect viral RNA and signal an innate immune response inside the cell that is essential for limiting and controlling viral infections.

The signal induces the expression of many innate immune and antiviral genes and the production of antiviral gene products, pro-inflammatory cytokines, chemokines and interferons.

«This debris left by dead cells can mistakenly signal to the body that there is an infection that warrants immune action, triggering the innate immune system,» said Bruce A. Sullenger, Ph.D., director of the Duke Translational Research Institute.

Jessica Jang, the lead author of the research paper and a third - year UCR graduate student in microbiology, explained that resistin regulates the recruitment of innate immune cells called monocytes to the site of infection to produce inflammatory cytokines (small proteins that are important in cell signaling).

Now, the research group led by Professor Koji Yamanaka at Nagoya University revealed that deficiency of the innate immune adaptor TRIF, which is essential for certain Toll - like receptor (TLR) signaling cascades, significantly shortened survival time of ALS mice.

Resolvin D - 1 is a bioactive mediator produced by immune cells for cell - to - cell signaling, and it is part of the natural innate immune response that resolves inflammation.

In 2008, he joined the group of Caetano Reis e Sousa at the Cancer Research UK (CRUK) London Research Institute and later joined the Francis Crick Institute, where he was awarded Marie Curie and EMBO long - term postdoctoral fellowships to investigate innate immune receptors and signaling pathways that trigger dendritic cell activation and drive T - cell responses against viruses or tumors.

TNA3: BPRC will offer access to its library of human cell reporter assays for the identification of innate immune receptor - induced signalling cascades, including human cell lines transfected with PAMPs such as TLR and / or engineered to express luciferase in response to NF - kB or IFRE - mediated signal transduction, and cell lines that provide insight into the intracellular signalling cascades of innate immune receptors.

ATP hydrolysis enhances RNA recognition and antiviral signal transduction by the innate immune sensor, laboratory of genetics and physiology 2 (LGP2).

TLR signaling mediated by MyD88 is required for a protective innate immune response by neutrophils to Citrobacter rodentium.

Thus, any events that could potentially activate DDR could trigger the activation of innate immune responses in the absence of DNA damage; similarly suppressing DDR signaling in the presence of tolerable DNA damage levels could alleviate some of the pathological features associated with DNA damage - driven inflammation.

While homology - based approaches are likely to be reliable for well - conserved pathways such as the core signaling components of the innate immune network, it is difficult to confidently assign function to the numerous proteases, protease inhibitors, and similarly diverse gene families in the absence of direct functional information.

We have used B. anthracis to study the effect of MAPK signaling pathways in group 3 innate immune lymphocytes (ILC3s).

In models lacking NLRX1, innate immune cells called macrophages produce higher levels of IL - 6, a signaling molecule that has a central role in colorectal cancer development.

The range of subjects includes, but is not limited to, immune cell development and senescence, signal transduction, gene regulation, innate and adaptive immunity, autoimmunity, infectious disease, allergy and asthma, transplantation, and tumor immunology.

Signaling through innate immune receptors promotes commensal bacteria colonization of the gut.

In this study we have shown that a bacterial toxin perturbs signaling pathways in ILC3s, down - modulating the innate immune response.

There is also growing evidence that the protein - coding repertoire of the innate immune system is rapidly evolving in insects [5], [8]--[11], even though comparative genomic analysis reveals the existence of a conserved core of immune signaling pathways in most insects [12]--[15].

Interferon signaling is central to the innate immune system, so answers to these questions also can lead to better understanding of cancers and diseases and new drugs related to immune activity or malfunction.

He will now investigate a set of molecules called TLR agonists that act through receptors on the surfaces of innate immune cells to set off a chain reaction of molecular signaling and activation within the immune system, which includes activation of latently infected CD4 cells.

Certain metabolites, such as fatty acids, ceramides and cholesterol crystals, elicit inflammatory responses through pathogen - sensing signalling pathways, implicating a maladaptation of macrophages and the innate immune system to elevated metabolic stress associated with overnutrition in modern societies.

BPRC will offer access to its library of human cell reporter assays for the identification of innate immune receptor - induced signalling cascades, including human cell lines transfected with PAMPs such as TLR and / or engineered to express luciferase in response to NF - kB or IFRE - mediated signal transduction, and cell lines that provide insight into the intracellular signalling cascades of innate immune receptors.

LUMC offers an extended multiplex transcriptome profiling assay (dcRT - MLPA) for monitoring innate, adaptive and inflammatory immune - response signalling gene signatures, which can be used to evaluate and improve immunisation strategies.

Genetic analysis revealed that Clostridia caused innate immune cells to produce high levels of interleukin - 22 (IL - 22), a signaling molecule known to decrease the permeability of the intestinal lining.