Sentences with phrase «innate immune system cell»

To account for individual differences in cell types, such as that potentially produced by a shift toward pro-inflammatory innate immune system cell types, a regression calibration approach similar to that developed by Houseman et al. (2012) was performed.

Since macrophages travel throughout the body and live for a long time, the β - Glucan fragments in the macrophages spread throughout the body and are recognized by other innate immune system cells.

Likewise, a changed distribution of inflammation related cells, such as an increase in the proportion of innate immune system cells such as monocytes (aka CD14 cells) relative to T or B cells (aka CD4, CD8, and CD19) could indicate a shift toward a pro-inflammatory response pattern.

Not exact matches

The initial immune response involves cells of the body's innate immune system, such as macrophages and neutrophils.

Macrophages are a type of white blood cell critical to the innate immune system.

Initially the innate immune system protects the tissue against these triggers, but prolonged activation becomes self - perpetuating, causing brain cell death to occur.

The innate immune system is the first line of defense in cells, and normally distinguishes molecules that belong to the body from foreign, disease - causing, molecules.

«We've solved a mystery, revealing a new aspect of our innate immune system and what flu has to do to get around it,» says Nicholas Meyerson, a postdoctoral researcher in the BioFrontiers Institute and lead author of a paper published in the Nov. 8 issue of Cell Host and Microbe.

As with innate immunity, the adaptive immune system — the T cells and antibodies produced by B cells that target specific molecules on invading cells — contributes to pathology or may also fight against it.

Along with improved potency and safety, the system saves time by providing easy, ready - touse RNA reagents that also reduce cell toxicity by avoiding activation of cellular innate immune responses.

In a report on their experiments, published April 2017 in the Proceedings of The National Academy of Sciences, the researchers say they found evidence that microglia, a cell type found in most vertebrae innate immune systems, affect the Müller glia's regenerative response and can be harnessed to accelerate the growth of new tissue in the retina.

Natural killer cells (also known as NK cells, K cells, and killer cells) are a type of lymphocyte (a white blood cell) and a component of innate immune system.

Cells in the innate immune system respond immediately by secreting inflammatory factors called cytokines to stop the spread of infection.

Areas covered range from basic studies into the biology of innate and adaptive immunity (immune cell development and differentiation, immunogenomics, systems immunology, structural immunology, antigen presentation, immunometabolism, and mucosal immunology) to immune contributions to health and disease (host defense, inflammation, cancer immunology, autoimmunity, allergy, transplantation, and immunodeficiency).

New research shows that all - trans - retinoic acid (atRA), the active form of vitamin A, regulates immune system responses in the mouse intestine by controlling expression of the protein HIC1 in cells known as innate lymphoid cells.

Until now, most researchers have focused on one of two strategies: attacking tumors with antibodies, which activate the innate immune system, or stimulating T cells, which form the backbone of the adaptive immune system.

Researchers at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) have discovered that innate lymphoid cells, early responders of the immune system, are primed at the DNA level for rapid action.

They may also draw the attention of cells belonging to the innate immune system, such as natural killer cells, which can destroy tumor cells.

According to Simon Rauber, an immunologist in Erlangen and primary author of the study, a previously inadequately studied cell population of the immune system called innate lymphoid cells plays a major role in the resolution of inflammations.

Because the innate immune system wasn't killing off infected cells, the mice showed an increased viral load and delayed recovery.

In the studies led by Kanneganti, Kuriakose and colleagues first sought to identify the specific machinery that the innate immune system uses to induce cell suicide.

This temporary colonization of E.coli in the mother affected the immune system of her offspring; after birth, the offspring harbored more innate lymphoid and mononuclear cells in their intestines compared to mice born to microbe - free pregnant mothers.

St. Jude Children's Research Hospital immunologists have identified the protein trigger in the body's quick - reaction innate immune system that specifically recognizes the influenza virus in infected cells and triggers their death.

«This debris left by dead cells can mistakenly signal to the body that there is an infection that warrants immune action, triggering the innate immune system,» said Bruce A. Sullenger, Ph.D., director of the Duke Translational Research Institute.

The research team, a collaborative partnership between the groups of Professor Gabrielle Belz of Melbourne's Walter and Eliza Hall Institute, and Professor Eric Vivier at the Centre d'Immunologie de Marseille - Luminy, France, found that innate lymphoid cells (ILCs) are crucial for protecting against bacterial infection in people with compromised immune systems.

The innate immune system refers to the front - line defenders — the cells and molecular mechanisms that attack pathogens.

They make up the primitive innate immune system of the slug and play the same role as immune cells in animals.

Monocytes and macrophages are two important white blood cells of the innate immune system.

According to the researchers, the trainability of cells from the innate immune system opens up many opportunities for applications.

Innate immune system discriminates between RNA containing bacterial versus eukaryotic structural features that prime for high - level IL - 12 secretion by dendritic cells.

Based on empirical data obtained in cases of chronic myeloid leukemia, a myeloproliferative syndrome controlled by the immune system, and in solid tumors, we observe both the possible contribution of innate CD8 (+) T cells to cancer disease control and their susceptibility to tumor immune subversion.

natural killer (NK) cells - a type of cytotoxic lymphocyte that constitute a major component of the innate immune system.

With respect to biological applications, the group is focusing on how cellular heterogeneity and cell - to - cell communication drive ensemble - level decision - making in the immune system, with an emphasis on «two - body» interaction (e.g., host cell - virus interactions, innate immune control of adaptive immunity, tumor infiltration by immune cells).

Vα14 invariant NKT (Vα14 iNKT) cells are a population of T lymphocytes that have several unique characteristics; many of these are related to their ability to function similarly to cells of the innate as opposed to the adaptive immune system.

This draws the innate immune system's natural killer (NK) cells into the fray, promotes the antibody - mediated destruction of malignant cells and, ultimately, supports the activation of T cells that specifically target the cancer.

The generation of these T cell subsets depends on the action of cytokines such as IL - 6, IL - 12 and IL - 23, produced mostly by cells of the innate immune system.

Specifically, inflammatory cells of the innate immune system have been shown definitively to have tumor - promoting activity.

Charles Janeway introduces the hypothesis that «components of the innate [immune] system, especially antigen - presenting cells such as DCs, required the microbial stimuli contained in [adjuvants] to become activated and acquire the capacity to induce productive responses from antigen - specific lymphocytes.

Our laboratory is interested broadly in the interface between the innate and adaptive immune systems, and the unique subsets of T lymphocytes that bridge these systems by adopting properties that are very characteristic of innate immune cells.

NK cells are a key part of the innate immune system with the ability to recognize and kill diverse types of tumor cells, including ovarian cancer.

This team plans to conduct the first human clinical trial combining these two therapeutic strategies (which have been tested separately and have shown activity in reducing HIV in humans), with the expectation that a boosted innate immune system empowered with unique antibodies to target HIV - infected cells will achieve greater reductions in HIV than observe previously.

Immune Regenerative Medicine is the field of medicine which encompasses numerous strategies used to improve the body's healing response in restoring the cells and function of the innate and adaptive immune system.

She and her colleagues study the cellular and molecular aspects of the innate and adaptive immune responses (the two arms of the immune system), and more specifically, dendritic cells, a specialized subset of leukocytes that coordinate them.

Topics covered will include how the immune system and commensal microbes interact in the context of health and disease; how dendritic cells respond to infectious or inflammatory stimuli and the roles they play in the induction and polarization of adaptive immune responses against pathogens; how the innate immune pathways regulate inflammation at mucosal barrier tissue sites and how the macrophages are involved in intestinal inflammation.

In addition to drugs and gene constructs, there's another strategy in the works for eliminating senescent cells: enhancing the innate immune system's ability to purge them.

This new marker of senescent cells is recognized by a naturally occurring IgM antibody that belongs to the innate immune system and is likely to be involved in a natural mechanism of immune recognition and clearance of senescent cells.

Natural killer (NK) cells are lymphocytes that are essential in the innate immune system.

There is already evidence that senescent cells are targeted by the innate immune system.

Stimulation of the STING pathway appears essential to generate a de novo immune response comprising tumor cell death, generation of antigens, and activation of the innate and adaptive immune system.

A phase 1 trial of a dendritic cell (DC) vaccine administered with imiquimod, a TLR7 agonist that stimulates the innate immune system, for patients with malignant glioma and glioblastoma (NCT01808820).