Sentences with phrase «innate lymphocyte»

Although GMCSF is mostly known for its role in inflammation, Dr. Merad's laboratory discovered that GM - CSF is produced in the normal gut by specialized cells called innate lymphocyte cells (ILCs) in response to microbiota signals.

I am interested in gaining a better understanding of why this class of innate lymphocytes are so critical for protection against S. pneumoniae in mice, with the ultimate goal of harnessing the potential of these cells for human therapeutics.

Combined with our data on ILC3s, it appears that B. anthracis modulates many subsets of innate lymphocytes, potentially through conserved mechanisms.

Less is known regarding the role of innate lymphocytes in B. anthracis infection.

Recent studies have revealed a critical role for innate lymphocytes (ILCs) in barrier maintenance [7, 8].

Not exact matches

He said that the most exciting arenas of immunology today include new strategies for vaccines and studies of regulatory T lymphocytes and the innate immune response, which is essentially the most general form of attacking pathogens.

Natural killer cells (also known as NK cells, K cells, and killer cells) are a type of lymphocyte (a white blood cell) and a component of innate immune system.

The scientists have demonstrated that this highly potent signal is able to alert cells related to lymphocytes, group 2 innate lymphoid cells (ILC2).

Another unconventional T cell subset with some features of innate immune cells is the intestinal intraepithelial lymphocytes (IEL) that express CD8αα homodimers, but neither CD4 nor CD8αβ.

natural killer (NK) cells - a type of cytotoxic lymphocyte that constitute a major component of the innate immune system.

Mucosal associated invariant T cells (MAIT) are innate T lymphocytes that detect a large variety of bacteria and yeasts.

Vα14 invariant NKT (Vα14 iNKT) cells are a population of T lymphocytes that have several unique characteristics; many of these are related to their ability to function similarly to cells of the innate as opposed to the adaptive immune system.

Charles Janeway introduces the hypothesis that «components of the innate [immune] system, especially antigen - presenting cells such as DCs, required the microbial stimuli contained in [adjuvants] to become activated and acquire the capacity to induce productive responses from antigen - specific lymphocytes.

Research Focus: My research focuses on the role of the herpesvirus entry mediator (HVEM) of by Innate Lymphoid Cells (ILC) and intraepithelial lymphocytes (IEL) in the Intestine.

Our laboratory is interested broadly in the interface between the innate and adaptive immune systems, and the unique subsets of T lymphocytes that bridge these systems by adopting properties that are very characteristic of innate immune cells.

The main mechanism includes phagocytosis of macrophages which play a critical role in nonspecific defense (innate immunity) and, moreover; they have a role as antigen presenters which also help initiate specific defense mechanisms (adaptive immunity) by recruiting other immune cells such as lymphocytes.

Natural killer (NK) cells are lymphocytes that are essential in the innate immune system.

We have used B. anthracis to study the effect of MAPK signaling pathways in group 3 innate immune lymphocytes (ILC3s).

Reduced levels of secreted IL - 22 in heterogeneous lymphocyte mixtures of Rag1 - / - splenocytes could be due to another cell affecting ILC3 production of IL - 22 and / or modulation in IL - 22 from other innate immune cells that have been reported to produce low levels of IL - 22, such as DCs or neutrophils [22, 42, 43].

Innate - like lymphocytes were responsive to CCL20 by in vitro migration assays (Figure 4C).

In this study, we found IL7RαhiCcr6 + innate - like lymphocytes were mostly LN resident and they produced IL17 within hours of bacterial or fungal challenge.

Our conclusion that LFA1 and ICAM1 function during innate - like lymphocyte movement from the SCS into the LN parenchyma is based on four sets of observations in mice treated with αL blocking antibody: (1) innate - like lymphocytes transiently accumulate in the SCS; (2) the accumulated cells exhibit an unusual elongated morphology (suggesting a less adhesive state); (3) tracking analysis shows reduced numbers of cells migrating from the SCS into the parenchyma; (4) the cells are more sensitive to dislodgement by CD169 blocking antibody.

Visual inspection of the imaging data for FTY720 - treated versus control LNs suggested that there were fewer Cxcr6GFP / + innate - like lymphocytes in the SCS after FTY720 treatment and less examples of cells migrating into the sinus (Video 3).

A similar increase in the frequency of Thy1 - PE labeled innate - like lymphocytes was observed in Icam1 - / - mice compared to littermate controls (Figure 6E).

(A) CD169 - Fc binding of innate - like lymphocytes.

Importantly, the blebs only become bound to cells that are associated with the macrophages at the time of isolation since co-preparation of LN cells from congenically distinct animals did not lead to cross acquisition of macrophage - derived blebs by innate - like lymphocytes from the different LNs (Gray et al., 2012).

The greater CD169 coating of Vγ4 + γδT cells and their stronger dependence on CD169 for retention in the SCS than the other innate - like lymphocytes suggests these cells interact more strongly or in a more selective way with CD169 + macrophages.

These cells, referred to as innate - like lymphocytes, position themselves at the exposed surfaces of the lymph node — the locations where microbes are most likely to enter the organ.

However, given the heterogeneity of the innate - like lymphocyte population, we can not exclude the possibility that LFA1 blockade also decreases retention of some cells within the LN parenchyma, thereby increasing their movement into the SCS.

These data support the conclusion that S1pr1 acts intrinsically in innate - like lymphocytes to promote close associations with SCS macrophages.

We show that CD169 supports adhesion of innate - like lymphocytes in the sinus and helps restrain them against lymph flow.

Thank you for submitting your article «Mechanism of innate - like lymphocyte surveillance of the subcapsular sinus to provide lymph node barrier immunity» for consideration by eLife.

These data indicate that, unlike short - term integrin blockade, long - term deficiency of ICAM1 or sustained blockade of LFA1 causes a loss of innate - like lymphocytes from the LN.

In an effort to reveal a role of CD169 in sinus retention of the total innate - like lymphocyte population, we blocked αL prior to blocking CD169.

With regard to cell - type variation, we examine variation in concentration of cell - types in lymphocyte pellets to identify variation that may reflect relatively greater responsiveness of the innate vs. the acquired immune system.