Sentences with phrase «inner ear development»

It is thought that this line of research can greatly contribute to the development of a fundamental treatment for hereditary hearing loss and inner ear development research.

The team says that this was one of the most compelling aspects of their study, because it speaks to the remarkable plasticity that exists in the genetic programs regulating inner ear development.

The specific health benefits include better respiratory health, muscle tone and inner ear development.

Not exact matches

Genetic variations most strongly associated with high scores were found near the GATA2 gene — involved in the development of inner ear hair cells and the inferior colliculus.

Heller's team produced the inner - ear hair cells by exposing embryonic cells in the lab to chemical factors which steer the natural development of hair cells.

They investigated whether overexpression of Isl1, an inner ear progenitor gene with roles in development and differentiation, could be effective in protecting the inner ear.

The GJB6 gene encodes the CONNEXIN 30 protein, which is essential in hearing development, and a deficiency of the gene results in the second most common disease among cases of hereditary hearing loss that have no other disease in the inner ear.

By culturing human stem cells in this manner and treating them with specific signaling molecules, the investigators were able to guide cells through key processes involved in the development of the human inner ear.

«This is essentially a recipe for how to make human inner ears from stem cells,» said Dr. Koehler, lead author of the study and whose research lab works on modeling human development.

The researchers inserted the genes about a week before birth — after they could identify tissue that would become the inner ear and before the natural development of hair cells had begun.

Hoxa1 lineage tracing indicates a direct role for Hoxa1 in the development of the inner ear, the heart, and the third rhombomere.

NeuroD - null mice are deaf due to a severe loss of the inner ear sensory neurons during development.

With Biogen's expertise in neuroscience research and drug development and Ionis» leadership in RNA targeted therapies, the companies plan to advance antisense programs for a broad range of neurological diseases including dementia, neuromuscular diseases, movement disorders, diseases of the eyes and inner ear, and neuropsychiatry.

For example, one study recently showed these signals act in concert to induce development of the inner ear.

We found widespread expression of Chd7 in early development of the mouse in organs affected in CHARGE syndrome including eye, olfactory epithelium, inner ear and vascular system.

We report here that inner ears of Lcc / Lcc mice fail to establish a prosensory domain and neither hair cells nor supporting cells differentiate, resulting in a severe inner ear malformation, whereas the sensory epithelium of Ysb / Ysb mice shows abnormal development with disorganized and fewer hair cells.

Cochlear (inner ear) development occurs normally to that point, but the blood supply to the cochlea (the stria vascularis) degenerates, so the hair cells of the cochlea die.