Conducted
insecticide resistance monitoring and entomology surveys especially before and after outdoor residue spraying done for pest control.
Martin's primary research interest is the evolution of
insecticide resistance in the malaria mosquito Anopheles gambiae.
His work on aphids has broadened to examine the molecular basis of all aphid interactions with their environment, including the genetic and epigenetic factors controlling aphid polyphenism and the molecular basis of
insecticide resistance.
Insecticide resistance is typically associated with alterations to the insecticidal target - site or with gene expression variation at loci involved in insecticide detoxification.
This includes Genome - Wide Association Studies (GWAS) to identify genetic loci associated with
insecticide resistance and population genetic studies to describe population sub-structuring.
In order to develop field - applicable diagnostics for Vgsc CN, and as a prelude to investigating the possible association of CN with
insecticide resistance, three assays were compared for their accuracy in CN estimation in this species.
The scale and scope of these data are enabling genotype - phenotype association studies to identify genetic determinants of pathogen virulence and drug /
insecticide resistance, and phylogenetic studies to track the origin and spread of disease outbreaks.
The sustainability of malaria control in Africa is threatened by the rise of
insecticide resistance in Anopheles mosquitoes, which transmit the disease.
Insecticide resistance in malaria vectors could presage a catastrophic rebound in disease incidence and mortality.
Insecticides are designed to kill insects and they can be very effective, although the development of
insecticide resistance can affect their level of control.
Conclusions / significance: Taken together, the microsatellite and
both insecticide resistance target - site markers provide evidence that in the face of intense gene flow among populations, disjunction in resistance frequencies arise due to intense local selection pressures despite an absence of insecticidal control interventions targeting Culex.
Topics this year include genomic epidemiology of the host, vector and parasite, highlighting the practical relevance of this research to global health, including anti-malarial drug resistance,
insecticide resistance, vaccine design, and mechanisms of protective immunity.
Genome sequences of Anopheles gambiae sister species help to investigate
insecticide resistance
The meeting explored the genomic epidemiology of the host, vector and parasite, highlighting the practical relevance of this research to global health, including antimalarial drug resistance,
insecticide resistance, vaccine design, and mechanisms of protective immunity.
This new data set is a quantum leap in terms of the breadth and depth of data now available for researchers studying how the species has become such an effective transmitter of malaria, and tracking the emergence and spread of
insecticide resistance.
The four genes currently shown with data are all associated with
insecticide resistance (although this is not a requirement).
The results of the randomized, controlled trial are important because some public health departments in places where Zika and dengue viruses are endemic do not necessarily monitor for
insecticide resistance.
The proof that this particular enzyme is also a marker for resistance to pyrethroids, gives us a further opportunity to monitor the rate of
insecticide resistance and make evidence based decisions in line with national plans.»
«Even with the decline of other mosquito vectors our study shows the difficulty posed by
insecticide resistance in terms of malaria elimination,» continued Professor Hemingway.
Such tools will allow control programs to detect and track resistance at an early stage in the field, which is an essential requirement to successfully tackle the growing problem of
insecticide resistance in vector control.
Insecticide resistance remains a major threat to malaria control.
But Read has demonstrated that targeting older mosquitoes — those nearing the end of their reproductive lives, which are also the most likely to be disease carriers — could largely eliminate the problem of
insecticide resistance.
«Largest genetic study of mosquitoes reveals spread of
insecticide resistance across Africa: New intelligence to help towards campaign against malaria in Africa.»
The largest ever genetic study of mosquitoes reveals the movement of
insecticide resistance between different regions of Africa and finds several rapidly evolving
insecticide resistance genes.
Our study highlights the severe challenges facing public efforts to control mosquitoes and to manage and limit
insecticide resistance.»
Unexpectedly, the researchers discovered many previously - unknown genetic variants within those genes that could be causing
insecticide resistance.
Engineered crops might also foster
insecticide resistance.
The pest is difficult to control because of the widespread occurrence of
insecticide resistance.
Insecticide resistance is going to matter at a certain point, he says — «What we don't know is whether we are just approaching that point, whether it is 1 year away, or five or 10.»
INSECTICIDE resistance in malarial mosquitoes could be wiped out for good, paradoxically by using slow - killing agents.
«I think
insecticide resistance is a time bomb.»
«Nobody dreamt that
insecticide resistance would spread the way it has spread throughout Africa.»
Noting that insects have been evolving resistance to natural plant defenses for millions of years and that this year marks the 100th anniversary of the first reported case of
insecticide resistance, he concludes, «Finding ways to delay resistance is a never - ending challenge with any pest management approach.»
Not exact matches
What I have described is a thoroughgoing neo-Darwinian interpretation of the evolution of
resistance to an
insecticide by insects.
In addition, planthoppers rapidly develop
resistance to
insecticides; in some parts of China, this
resistance can reach 200-fold.
The focus on bio-rational products is to ensure minimum pest
resistance by the army worms, which is higher with the use of synthetic
insecticides.
Bedbugs are evolving
resistance to a common
insecticide that once killed them.
In theory, spraying two different types of
insecticide at once postpones
resistance, as bugs that resist one type are killed by the other.
A study found that as many as 80 percent of the bugs are immune to
insecticides in over-the-counter shampoos, and
resistance will only increase.
But when the massive rollout of
insecticide - treated bed nets began in Africa in the early 2000s — more than a billion have been distributed — little thought was given to
resistance, says Maureen Coetzee, director of the Wits Research Institute for Malaria at the University of the Witwatersrand in Johannesburg, South Africa.
The Colorado potato beetle has gone through whole sequences of
insecticides and developed
resistance.
However, this strategy is often ineffective because the pest has developed
resistances against nearly all
insecticides.
Mosquitoes are also increasingly developing
resistance to common
insecticides.
As mosquitoes develop
resistance to pyrethroid
insecticides, researchers are forced to look for alternatives
When they inserted those genes into crop genomes, through a technique called recombinant DNA, the plants were able to produce the protein for bug
resistance on their own, eliminating the need to spray
insecticide.
Malaria is transmitted by mosquitoes and rising
resistance to
insecticides is hampering efforts to control the disease.
Professor Martin Donnelly, a corresponding author from the Liverpool School of Tropical Medicine and Honorary Faculty at the Wellcome Trust Sanger Institute, said: «We know that mosquito populations are rapidly evolving
resistance to
insecticides, which is a serious threat to the future of malaria control in Africa.
Public health measures in Africa such as
insecticide - treated bed nets and
insecticide - spraying have helped reduce the numbers of malaria cases since 2000, but many mosquitoes have evolved
resistance to
insecticides.
While the main malaria vector in South Africa, Anopheles funestus, is susceptible to DDT, a secondary vector, A. arabiensis, has developed
resistance to DDT and other
insecticides.
«DDT
resistance in Africa as well as several other parts of the world has been acquired because of massive use of these
insecticides for crop protection,» Guillet says.