The researchers discovered that NS1 has a 3D structure with two distinct sides, one facing the replication system of the virus
inside cells it infects and the other facing the immune system outside infected cells.
Not exact matches
The study showed the protein also rearranges itself into rings in order to bind RNA and control the internal components of the virus copied
inside infected cells.
Ordinarily, malaria - causing parasites seal themselves behind two membranes
inside red blood
cells of
infected people.
Knowing more about how viruses get
inside cells, says Pelkmans, could lead to the development of drugs that prevent the virus from
infecting the
cell rather than simply trying to slow down replication after the infection takes hold.
After a week, they saw endothelial
cells in the brain that were
infected, as well as evidence that the parasite was reproducing
inside those
cells.
Another idea, «beloved of microbiologists,» Hunter said, is the Trojan horse hypothesis, in which the parasite hitches a ride across the barrier while hidden
inside an
infected host
cell.
The distinction between apoptosis and
cell lysis is important in immunology - lysing a virus -
infected cell would only release the virions, whereas apoptosis leads to destruction of the virus
inside.
Using a powerful imaging technique that allowed the scientists to track the presence and movement of parasites in living tissues, the researchers found that Toxoplasma
infects the brain's endothelial
cells, which line blood vessels, reproduces
inside of them, and then moves on to invade the central nervous system.
Follow - up studies showed that the two antibodies isolated from the Ebola patient work by interfering with a critical step in the process by which ebolaviruses
infect cells and then multiply
inside them.
They found that the
infected cultures responded to the drugs in the same way that liver
cells inside the body are known to do.
«Once a liver
cell is
infected, the viral genome persists
inside the nucleus, and that can reactivate later,» says Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and Electrical Engineering and Computer Science.
A virus
infects and causes sickness by entering a
cell and making copies of itself
inside the host
cell.
They engineered a genetically modified HIV virion that was capable of
infecting the
cell but incapable of reproducing
inside it.
His lab's technique embeds two biomolecular tags — a «red» tag and a «green» tag, so - called because of the fluorescent antibodies that detect them —
inside an
infected cell.
From the liver it goes back into the bloodstream,
infecting and multiplying
inside red blood
cells.
Apparently, antibodies to this protein protected against malaria by trapping the schizont
inside the red blood
cell — not by preventing it from
infecting new ones.
After 30 years of research to cure HIV infection and AIDS, this opens a whole new avenue in understanding how scientists could track and find
infected cells, then wake up and kill the virus hiding deep
inside.
The protein, NS1, is produced
inside infected cells, where it plays a key role in replication of the virus.