Any tangle - acting drug must cross the blood - brain barrier to enter the brain, and must also penetrate
inside nerve cells in affected brain regions.
Neurofibrillary tangles are collections of abnormally twisted protein strands
found inside nerve cells, and they are primarily made up of a protein called tau.
Brain cells translate that genomic gobbledygook into rogue proteins, which do bad
things inside nerve cells and eventually trigger symptoms, such as involuntary movements.
A new scientific study reveals one way to stop proteins from triggering an energy
failure inside nerve cells during Huntington's disease.
His recent study published in Nature Communications characterized one protein, valosin - containing protein (VCP) that Qi's research team found in high
abundance inside nerve cell mitochondria.
In contrast, the tau protein wreaks
havoc inside nerve cells, causing the accumulation of spaghetti - like strands that choke the neurons.
Alpha - synuclein is the primary structural component of Lewy bodies, which are clumps of protein that
develop inside nerve cells in Parkinson's disease and some other disorders.
Using the standard timing protocol, the two enzymes do not reach peak
activation inside a nerve cell at the same time, a hint that the usual way of doing things might not be the best way.
The other most cited key player is tau, another Alzheimer's - associated protein that abnormally aggregates into threadlike
tangles inside nerve cells.
These are the senile plaques, which are found outside of nerve cells, and the neurofibrillary tangles,
found inside nerve cells.
FUS proteins can change back and forth from small liquid droplets (resembling oil droplets in water) to small gels (like jelly)
inside nerve cells.