The study, published in Nature Genetics, offers the possibility that targeting these processes,
instead of single genes, may provide new opportunities for treatment of Wilms tumor.
Not exact matches
However, cancer cells may
instead be coaxed to turn back into normal tissue simply by reactivating a
single gene, according to a study that found that restoring normal levels
of a human colorectal cancer
gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.
Others might be engineered to include nutrients like beta carotene, iron, and vitamin A.
Instead of one
gene to fight off insects or disease, crops will be engineered with «stacks»
of resistance
genes to prevent pests from evolving resistance to a
single approach.
Last autumn Jean Weissenbach and Marc Lathrop came up with a new type
of genetic map which makes it possible to map most
single genes in «months
instead of years», according to Nigel Spurr, a cancer researcher and
gene mapper at the Imperial Cancer Research Fund.
Instead, Werren likened the functionality
of these
single - copy
genes to «moonlighting» for extra cash, with the
genes taking on a «night job» in the venom gland in addition to their «day job» elsewhere in the body.
PENCIL IT IN Scientists have used two new versions
of CRISPR
gene editors, which rewrite DNA like pencils
instead of cutting like scissors, to change
single - letter typos that cause some blood disorders.
Instead of the simple manipulation
of single genes, he wants to engineer many
genes to work together, like transistors wired in a circuit.
In the years after finding the CFTR
gene at the root
of the disease, Collins, Tsui and others discovered the situation was far more complex than they had ever dreamed:
Instead of just a
single mutation in the
gene, researchers found some 1,900 distinct mutations.
With PrediXcan, validation studies only need to test a few thousand
genes at most,
instead of millions
of potential
single mutations.
Similar results are observed in DE analyses
of real data where the use
of count sums
instead of single - cell counts improves specificity and the ranking
of relevant
genes.