Levels of NAD dropped, and the neural stem cells stopped dividing; they stopped renewing themselves; and they stopped being able to create important cells that
insulate axons, the «wires» that carry electrical signals throughout the brain.
However, Schwann cells laying more far away from the bloodstream can neither synthesise their own lipids nor obtain them well from the blood and therefore can not
insulate the axons sufficiently — if at all.
Our goal is to use a new imaging system to monitor damage caused by AD to the brain region that contains
the insulated axons (analogous to cables) connecting the neuron cell bodies (analogous to the central processing unit of a computer).
Throughout the teen years, fatty tissue starts to
insulate the axons from interfering signals — it is a bit like the plastic that coats electrical cables.
Not exact matches
The speed of transmission depends on several factors, including the diameter of the
axon and the thickness of the electrically
insulating myelin sheaths that surround the
axons.
Those signals are disrupted because myelin, the
insulating sheath around a nerve cell's message - transmitting
axons, becomes damaged.
The HMS study reveals that the aberrant behavior of an enzyme called RIPK1 damages neuronal
axons by disrupting the production of myelin, the soft gel - like substance enveloping
axons to
insulate them from injury.
In vertebrates, the
axons of many neurons are sheathed in myelin, which is formed by either of two types of glial cells: Schwann cells ensheathing peripheral neurons and oligodendrocytes
insulating those of the central nervous system.
This insulation, called myelin, is made up of numerous layers of cellular membranes — seen in cross section, an
axon insulated in this way resembles the rings of a tree.
These signals travel much faster when the
axon is wrapped in myelin, an
insulating layer of fats and proteins.
And in the relatively few
axons that were
insulated, the myelin also looked normal.
The slow speed of spikes (they travel about one foot per second in
axons that lack the
insulating sheathing called myelin) is one hundred - millionth the speed of signal transmission in digital computers.
Without myelin to
insulate neurons, signals sent down nerve cell
axons quickly lose power.
But the precise function of PMP22, a major component of the myelin sheath that surrounds and
insulates peripheral nerve cell
axons, has been unclear.
The myelin sheath requires a constant supply of high quality fat to
insulate and protect the enclosed
axons.
Myelin forms an
insulating layer around these
axons, the purpose of which is to allow electrical impulses to transmit efficiently and rapidly along the axonal pathways.