The phrase
"insulin receptor" refers to a special protein on the surface of cells that interacts with insulin. Insulin is a hormone that helps regulate blood sugar levels in our body. The
insulin receptor acts like a lock, and when insulin, the key, attaches to the receptor, it allows the cells to absorb glucose (sugar) from the blood. This process is important for maintaining normal blood sugar levels and providing energy to the cells.
Full definition
The insulin can then bind to
insulin receptors in the liver, muscles and fatty tissues, triggering a process that reduces glucose levels in the blood.
The problem in type 2 diabetes is not that there isn't enough insulin, but that the insulin present doesn't work very well due to impaired
insulin receptor sensitivity.
Insulin resistance occurs
when insulin receptors stop responding to insulin and do not allow glucose into the cells.
This increased inflammation damages the cell membranes of the body
causing insulin receptor distortion that leads to insulin resistance (2).
Studies show the immune compounds that cause inflammation also make
insulin receptors less sensitive, creating insulin resistance.
Insulin is a hormone that's highly prone to oxidation, and when it does, it becomes useless at stimulating glycogen
store insulin receptors.
While not all examples may apply specifically to the insulin /
insulin receptor problem, it may shed some insight into the problem and show us where to begin.
The increased calcium levels and
defective insulin receptors are believed to be responsible for the increased insulin resistance in type 2 diabetes patients.
To protect themselves from this excess energy and subsequent damage, our cells reduce the number
of insulin receptors on their surfaces.
And, when you exercise, your muscles need more energy to fire and
insulin receptor sites become more receptive.
It is released into the blood and travels though - out the body, landing on
insulin receptors on body cells.
It creates a type of insulin resistance which makes the cell's
insulin receptors less sensitive, and therefore causes you to burn less fat.
Decreased IGF type 1 receptor signaling in mammary epithelium during pregnancy leads to reduced proliferation, alveolar differentiation, and expression of
insulin receptor substrate (IRS)-1 and IRS - 2.
A dose of 1,000 mcg per day showed promising results in studies, and this is due to chromium's role in enhancing
insulin receptor activity.
Increasing blood levels of IGF - 1 to in turn increase collagen production is a very foolish idea; IGF - 1 increases sebum production by enhancing the sensitivity of
insulin receptor cells to insulin.
The scientists discovered that
blocking insulin receptors with a chemical called S961 led to a dramatic increase in beta cell replication.
That, in turn, leads to activation of a number of substrates, such as IRS - 1, IRS - 2; IRS is standing
for Insulin Receptor Substrate.
Mice
lacking insulin receptor in brain or on hypothalamic neurons display an array of metabolic abnormalities, however, the role of insulin action on astrocytes and neurobehaviors remains less well - studied.
This occurs in a number of ways, including reduction of glucose absorption, slowing down of carbohydrate digestion, stimulating the pancreas to produce more insulin, and stimulating
insulin receptors so that more sugar flows out of our bloodstream and into our cells.
Selective response to insulin versus insulin - like growth factor - I and - II and up - regulation of
insulin receptor splice variant B in the differentiated mouse mammary epithelium.
Now applying the concept to tumor formation, Rask - Madsen and his colleagues discovered similar signs of a pro-inflammatory state in the mice with
insulin receptors knocked - out in vascular endothelial cells.
Cinnamon, Shetty says, appears to be particularly helpful in slowing sugar uptake and
helping insulin receptors in the body work more effectively.
Either scenario may also occur due to refractoriness or exhaustion of the pancreatic islet cells and / or
cellular insulin receptors due to obesity and diets overly rich in simple carbohydrates and fat.
MHCI limits synapse density by
inhibiting insulin receptors, which regulate the body's sugar metabolism and, in the brain, promote synapse formation.
The Drosophila melanogaster gene insulin - like receptor (InR) is homologous to mammalian
insulin receptors as well as to Caenorhabditis elegans daf - 2, a signal transducer regulating worm dauer formation and adult longevity.
These protein and fat sources are extraordinarily critical for rebuilding healthy cell membranes with
normalized insulin receptor activity.
Patients with type II diabetes develop «insulin resistance» in
which insulin receptors become incapable of responding to insulin, the reason for which is unknown, Boulanger said.
Phrases with «insulin receptor»