Sentences with phrase «insulin signaling cascade»

Free fatty acid - induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

This is a very important - again, another transcription factor that regulates not glucose metabolism so much, but lipid metabolism and lipogenesis; and this is also under the regulation of insulin signaling cascade.

So, as you can see, this insulin signaling cascade, at least on this arm, regulates a number of aspects of metabolism; both carbohydrate and synthesis carbohydrate metabolism, as well as protein synthesis and metabolism.

Not exact matches

It's been shown that PTP1B not only regulates insulin receptor signaling, but also regulates a number of other signaling cascades, including oncogenic signaling pathways such as EGF receptor signaling, IGF - 1 receptor signaling, as well as cytokine signaling such as interferon gamma, and interferon alpha signaling cascades.

Now that I've introduced both insulin and leptin signaling cascades, I want to finish by talking about how they are integrated.

Now, this is actually a relatively simplified form of this cascade, and every day we're learning more about other factors that are involved in insulin signaling.

Activation of the insulin receptor involves its autophosphorylation, which is followed by phosphorylation of several target proteins in the signaling cascade.

The insulin receptor signaling cascade is inhibited by several phosphatases, including protein tyrosine phosphatase 1B (PTB 1B), phosphatase and tensin homolog on chromosome 10 (PTEN) and SH2 - domain - containing inositol phosphatase (SHIP2), all of which are inactivated by ROS.

Their metabolites accumulate in muscle and fat cells, activate proinflammatory signalling cascades, cause mitochondrial dysfunction, and interfere with insulin - stimulated glucose transport.

mTORC1 is the central component of the insulin - signaling cascade [insulin / insulin - like growth factor (IGF)-- phosphatidylinositol 3 - kinase (PI3K) pathway)(Fig. 1) that regulates protein synthesis and mRNA translation through 2 primary mechanisms: 1) inactivation of the repressor of mRNA translation, eukaryotic translation initiation factor 4E - binding protein 1 (eIF4E - BP1), and 2) the activation of 70 - kDa ribosomal protein S6 kinase.