Sentences with phrase «intact immune system»

Next, they grafted this lab - grown gene - altered skin onto mice with intact immune systems.

But until now, researchers have had a hard time studying ILCs because it hasn't been possible to selectively eliminate them in the context of an otherwise intact immune system.

Unlike other mice used to study the virus, the Hopkins mice have completely intact immune systems more similar to humans, which enable researchers to see all that is involved in mounting an immune response.

What I will stand up and scream is that newborns without intact immune systems and detoxification systems are being over-burdened with PRESERVATIVES AND ADJUVANTS IN THE VACCINES.

They argue that a more appropriate model, transplanting tumors from mice into genetically identical hosts with fully intact immune systems, would be more informative and clinically relevant.

This study, «Engineered epidermal progenitor cells can correct diet - induced obesity and diabetes,» is the first to show that an engineered skin graft can survive long term in wild - type mice with intact immune systems.

«We resolved some technical hurdles and designed a mouse - to - mouse skin transplantation model in animals with intact immune systems,» said study author Xiaoyang Wu, PhD, assistant professor in the Ben May Department for Cancer Research at the University of Chicago.

The ability of these children to maintain an intact immune system in the face of ongoing viral replication and in the absence of antiretroviral therapy can provide us with new insights into hitherto unknown defense mechanisms, which could eventually benefit other HIV patients,» says Professor Oliver T. Keppler, Chair of Virology at the Pettenkofer Institute, and former head of the German Reference Center for Retroviruses in Frankfurt am Main.

This study is the first to selectively target ILCs in the presence of an intact immune system, and these findings suggest that under normal conditions, ILCs play a critical role in dampening the anti-bacterial T - cell response using MHCII.

Because mice with intact immune systems are resistant to S. stercoralis infection, the researchers began with an immunocompromised strain of mice, and then exposed some to a synthetic steroid called methylprednisolone (MPA) that is commonly used to treat asthma in humans.

By administering Zika virus directly into the reproductive tract of pregnant mice that have an intact immune system, the researchers found that the Zika virus appears to create disorganization in the cellular layers of the placenta that keep toxins, bacteria and viruses from crossing.

These mice also do not have intact immune systems: Humans might develop antibodies to the monoclonals, rendering them ineffective.

In mouse models, carcinogen - induced tumors that arise in immunodeficient mice, when transplanted to wild - type mice, are usually eliminated by the intact immune system of the new host.

However, tumors induced in wild - type mice have arisen despite an intact immune system.

«We believe a major reason that follicular lymphoma is so amenable to immunotherapy is that there is a significant interaction between FL and the intact immune system,» said Westin.

Although pinworm infections are generally considered to be mildly or even non-pathogenic in animals with intact immune systems, they may interfere with research goals in a several ways.

When transplanted into wild - type mice with intact immune systems, these tumors are eliminated, presumably by T - cells.

An intact immune system is essential for maintaining our health and its dysfunctions are associated with increased susceptibility to infection or the development of inflammation, autoimmunity, allergy or cancer.

In a paper published online Aug. 31, by Nature Medicine, researchers report that using a monoclonal antibody called anti-CD47, which blocks the «don't - eat - me» signal on malignant cells, to treat mice with an intact immune system provides a much more lifelike way to study and develop an immune - based cancer therapy.