Sentences with phrase «integrated circulating leptin»
Our data directly address this hypothesis because we observed a decrease in leptin pulse amplitude between visit CRC1 and visit CRC2 (decreased peak minus nadir plasma leptin concentration and decreased AUC of the change in leptin) without a significant change in integrated circulating leptin concentration (leptin AUC).
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These authors speculated that, as for other endocrine systems (33,34), the CNS might interpret an increase in leptin pulse amplitude as a signal calling for a decrease in appetite independently from any change in the integrated circulating leptin concentration (32).