Not exact matches
Their main aim is to understand how mitochondria
interact with other
cellular components to maintain physiological homeostasis, and how mitochondrial defects lead to pathological states.
The research team has been using NMR — a technique related to the one used in MRI body scanners and capable of visualising molecules at the smallest scales — to examine how small
components of herpes virus help it to multiply by binding themselves with other large molecules; this produced images of a monkey herpes virus protein
interacting with mouse
cellular protein and viral RNA.
Environmental factors
interact with the different subgenomes to modify the transcription of their
component genes and to modulate the translation of protein products and their posttranslational modification, yielding changes in protein and
cellular function and metabolism, and defining an intermediate phenotype.
«By identifying the most important
cellular components that viruses hijack and re-wire, we can more intelligently design drugs that target the virus's weak points and where it
interacts with the host.»