Sentences with phrase «interactions in human disease»

Career Goals: I want to pursue my career in scientific research involving host - pathogen interactions in human disease.

Not exact matches

Kacey Ernst's primary research interests are in determining how human - environment interactions alter risk of vector - borne disease transmission.

Several species of protozoa reside in the human gut, and some of them are prevalent in patients with gastrointestinal disease, suggesting that similar host - parasite interactions could affect human health.

«It's a bit like human disease but in plants, to understand the pathogen and its interaction with the plant allows to develop a functional cure to treat the affected plants» emphasizes the specialist in plant genomics.

«In the future, such efforts could allow us to much better understand human - microbiome interactions, model malnutrition disorders and inflammatory diseases of the gut, and perform personalized drug testing,» said co-first author Alessio Tovaglieri, a Graduate Student at the Department of Health Science and Technology at ETH Zurich in Switzerland, who performs his thesis work on Ingber's teaIn the future, such efforts could allow us to much better understand human - microbiome interactions, model malnutrition disorders and inflammatory diseases of the gut, and perform personalized drug testing,» said co-first author Alessio Tovaglieri, a Graduate Student at the Department of Health Science and Technology at ETH Zurich in Switzerland, who performs his thesis work on Ingber's teain Switzerland, who performs his thesis work on Ingber's team.

«We know from previous human studies that changes in gut bacterial composition correlate with the early development of type 1 diabetes, and that the interactions between bacterial networks may be a contributing factor in why some people at risk for the disease develop type 1 diabetes and others don't,» said Jessica Dunne, Director of Discovery Research at JDRF, which funded the study.

The researchers» strategy — generating disease - specific nerve cells, identifying a causative gene for developmental defects, validating the gene - specific defect in animal models, and then investigating interactions with other genes both in animal models and in humans — represents a promising new approach for understanding the mechanisms underlying some of the most intractable psychiatric illnesses.

The interaction between the human host and microbes reflects a unique exposure that not only can lead directly to disease expression, but also can lead to changes in human host phenotype that is not directly pathogenic.

Thus, neural derivatives of disease - specific human pluripotent stem cells constitute a relevant biological resource for exploring the impact of adult - onset HD mutations of the HTT gene on the division of neural progenitors, with potential applications in HD drug discovery targeting HTT - dynein - p150Glued complex interactions.

The interaction between our human and microbial selves is being investigated in nearly every disease you can think of.

«This can shed new light on the evolution and interaction of diseases in human populations.

According to Ophir Klein, MD, PhD, the Charles J. Epstein Professor of Human Genetics and chief of the Division of Medical Genetics at UCSF, «We are looking forward to a close interaction between Dr. Rajkovic and our clinical genetics faculty members in Pediatrics, Obstetrics, Internal Medicine and the Cancer Center, as well as with our colleagues working on genetic diseases in other departments.

Importantly, defects in the interaction between the SECIS and a protein that we identified, SECIS - binding protein 2 (SBP2), have been linked to human diseases.

Should collaborations like these prove to be important also in human breast cancer, disrupting key interactions may be a novel treatment strategy for the disease.

In addition, projects to perform genetic interaction screens on disease genes in model organisms (yeast, worm, fly, fish) will not be considered, unless the project includes substantive specific aims that investigate the disease relevance of any new genes discovered in human or mammalian model systemIn addition, projects to perform genetic interaction screens on disease genes in model organisms (yeast, worm, fly, fish) will not be considered, unless the project includes substantive specific aims that investigate the disease relevance of any new genes discovered in human or mammalian model systemin model organisms (yeast, worm, fly, fish) will not be considered, unless the project includes substantive specific aims that investigate the disease relevance of any new genes discovered in human or mammalian model systemin human or mammalian model systems.

I am applying principles from physical and computational sciences to the study of biology to find patterns in these interactions, to obtain insight into population genetics, human evolution, and diseases including cancer.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

High - resolution maps of enhancer - promoter interactions in rare primary human T cell subsets and coronary artery smooth muscle cells link variants associated with autoimmune and cardiovascular diseases to target genes.

In her essay, she described how the interactions between genes and the environment affect human health and disease, concluding that these environmental influences on gene activity allow people to protect their own well - being by cultivating healthy habits.

Genetic epidemiology is a discipline takes care of studying the role of genetic factors and their interaction with environmental factors in the aetiology of human disease.

«The interaction between H. pylori and human ancestry entirely accounted for the difference in geographical disease risk,» said Kodaman, a graduate student based at Vanderbilt University, who is working and studying under Williams in the Department of Genetics at Geisel.

Conclusions: In an analysis of peripheral blood mononuclear cells and intestinal tissues from patients with inflammatory bowel diseases vs controls, we found that reactivity to intestinal bacteria is a normal property of the human CD4 + T - cell repertoire, and does not necessarily indicate disrupted interactions between immune cells and the commensal microbiota.

Arc is an activity - regulated neuronal protein, but little is known about its interactions, assembly into multiprotein complexes, and role in human disease and cognition.

An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease.

One wonders how many human diseases are caused by perturbations in host - microbe interactions, and how we could use this knowledge to prevent and / or treat such perturbations.

BIO * 235, Microbiology (4 credits / 6 contact hours) $ $ Laboratory Course Fee Gen Ed Competencies: Scientific Knowledge & Understanding, Scientific Reasoning This is an introduction to general microbiology.The course is designed to meet the needs of pre-allied health students as well as biology or science majors.Topics include the structure, physiology, and molecular biology of microorganisms as well as the interactions between microbes and their hosts, including their role in the environment.Students also learn how microbes are studied and how they can cause disease and yet are essential to human well - being.

External experts and stakeholders were invited to participate in the event in order to open and animate the discussion about companion animal responsible ownership, diseases transmitted by companion animals and the mutual benefits of the human - animal interaction.

Whenever any animal is carrying disease, use common sense and caution in interaction with humans with lowered immune systems, such as very young, geriatric, or immunocompromised individuals.