The Polonis lab has also employed both cell line - based model systems, as well as primary cell types from uninfected
humans, to investigate virus -
antibody - host cell
interactions and cross-subtype reactivities amongst the major subtypes
of the HIV pandemic.
• Disease - driving pathways that involve the
human immune system are often targeted by
antibodies, and Organ - Chips recreate complex
interactions of different
human cell types and aspects
of the
human immune system, overcoming limitations
of animal models which do not reflect all
human immune cells.