The current efforts of her laboratory are focused primarily on four areas of innate immunity: the molecular basis of pathogen recognition; innate immunity to malaria; Type I
interferon gene regulation; and counter regulation of innate immune recognition.
The involvement of NF - κB in β -
interferon gene regulation reveals its role as widely inducible mediator of signal transduction.
Not exact matches
For example, the study found down -
regulation of
genes involved in
interferon tau, the major signal of pregnancy recognition.
In 1984, he moved to the Institute for Molecular and Cellular Biology, at Osaka University (Osaka, Japan), where his research group continued to study the
regulation of
interferon genes and discovered the
interferon - regulatory - factor family of transcription factors.
Beginning with the pathogen pattern recognition receptors (PPRRs), the signal travels like clockwork through various molecular components and culminates in
interferon beta
gene regulation.
To understand
gene regulation, Panne works on a cell - free model of the human
interferon beta response to viral infection.