Moreover, she hasn't fallen nearly as ill from other viruses, suggesting her lack of IRF7 -
dependent interferon production may not leave her vulnerable to viruses overall — a situation the researchers say they have also noted with other mutations that underlie infectious disease.
«Surprisingly, we found that although HIV
inhibits interferon production it also stimulates more than twenty antiviral interferon - stimulated genes — or ISGs — in its key target cells.
The findings, published in the Journal of Virology, show how HIV induces antiviral interferon stimulated genes in the absence
of interferon production.
That could provide more understanding of miscarriage generally; other infections that cause congenital diseases, like toxoplasmosis and rubella; and autoimmune disorders that feature excessive type I
interferon production, such as lupus, she says.
«When a person is infected with HIV, the virus infects immune cells and knocks out the body's
interferon production; the first line of defence in our bodies.