Sentences with phrase «intestinal epithelial»

Cysteine protease activity of feline Tritrichomonas foetus promotes adhesion - dependent cytotoxicity to intestinal epithelial cells.

This occurs at the level of biliary canaliculi, intestinal epithelial cells, and renal proximal tubular epithelial cells.

P - glycoprotein is present on the luminal border of these intestinal epithelial cells where it transports drugs from the cytoplasm back into the intestinal lumen where they can be eliminated.

Short - chain fatty acids have numerous benefits, including supplying energy to the large - intestinal epithelial cells, stimulating intestinal sodium and water absorption, and lowering the pH in the large intestines — an environment that favors survival of beneficial bacteria in the GI tract.

When long - chain fatty acids are consumed, they are digested and absorbed into the small - intestinal epithelial cells; however, they are not transported directly into the blood supply but rather enter the lymphatics first.

Intestinal epithelial cell proliferation is dependent on the site of massive small bowel resection

Probiotics strengthen the intestinal epithelial barrier so that the damaging contents of the gut remain out of our bodies.

Green tea polyphenols inhibit the sodium - dependent glucose transporter of intestinal epithelial cells by a competitive mechanism

Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions.

Laparra et al. identified that Bifidobacteria co-administration diminished the inflammatory response activated by gliadin exposure to intestinal epithelial cells.

Together with the gut - associated lymphoid tissue and the neuroendocrine network, the intestinal epithelial barrier, with its intercellular tight junctions, controls the equilibrium between tolerance and immunity to non-self antigens.

Barriers called tight junctions guard the pathways between intestinal epithelial cells.

Hauri HP, Sterchi EE, Bienz D, Fransen JA, Marxer A. Expression and intracellular transport of microvillus membrane hydrolases inhuman intestinal epithelial cells.

Female athletes are at risk for common nutrient deficiencies, such as low protein, low iron, low calcium, and low vitamin D. (3) When active women don't eat enough nutrients, or they are poorly absorbed due to increased intestinal permeability (leaky gut), SIBO, SIFO, or other causes of intestinal epithelial inflammation, they are not nourished enough to sustain intense exercise over time.

Suzuki T. Regulation of intestinal epithelial permeability by tight junctions.

Circulating levels of... a marker of intestinal epithelial cell damage, were significantly elevated in the affected individuals and correlated with the immune responses to microbial products...

Intestinal epithelial tuft cells initiate type 2 mucosal immunity helminth parasites.

Objective: Human intestinal epithelial organoids (IEOs) are increasingly being recognised as a highly promising translational research tool.

The intestinal epithelial cells (IECs) that line the gut form a robust line of defense against ingested pathogens.

Efficient wound healing is required to maintain the integrity of the intestinal epithelial barrier because of its constant exposure to a large variety of environmental stresses.

For most of the cancer cells, 45 — 100 nM RIPK2 inhibitor 1 inhibited > 70 % of the proliferation of colon and blood cancer cells while preserving the proliferation of normal Rat - 1 and ModeK intestinal epithelial cells (Fig. 6A).

Therefore the group studies with sophisticated imaging technology in vitro and ex vivo: i) the molecular mechanism driving the migration of HIV through the intestinal epithelial barrier; ii) the cellular targets in the mucosa, in specific macrophages and DCs, to identify the possible pathways to invade the tissue and disseminate to other organs; iii) the involvement of DCs and their functional properties in mediating adaptive immune responses at mucosal level; and iv) the role of antibodies with different effector functions in changing the pathways of the virus.

16) Baas A.F., Kuipers J., van der Wel N.N., Batlle E., Koerten H.K., Peters P.J., Clevers H.C., Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

Microbial pathogenesis and the intestinal epithelial cell.

Chromosome - associated protein D3 promotes bacterial clearance in human intestinal epithelial cells by repressing expression of amino acid transporters.

The Intestinal Epithelial Cell Differentiation Marker ALPi is Selectively Induced by HDAC Inhibitors in Colon Cancer Cells in a KLF5 - dependent Manner.

Tumor necrosis factor alpha and inflammation disrupt the polarity complex in intestinal epithelial cells by a posttranslational mechanism.

L - Threonine induces heat shock protein expression and decreases apoptosis in heat - stressed intestinal epithelial cells.

Arginine stimulates cdx2 - transformed intestinal epithelial cell migration via a mechanism requiring both nitric oxide and phosphorylation of p70 S6 kinase.

The membrane is coated with proteins that support 3 - D cell growth and it's seeded with human intestinal epithelial cells (from a cell line originally isolated from a colon cancer).

Enterohemorrhagic E. coli alters murine intestinal epithelial tight junction protein expression and barrier function in a Shiga toxin independent manner.

Preterm infant gut microbiota affects intestinal epithelial development in a humanized microbiome gnotobiotic mouse model.

Our Intestine - Chip also allows researchers to culture intestinal epithelial cells alongside other cell types, such as immune cells, and analyze how these different cell types interact.

Extracellular Acidosis Stimulates NHE2 Expression through Activation of Transcription Factor Egr - 1 in the Intestinal Epithelial Cells.

Leveraging these technologies, the team generated expression profiles for a total of 53,193 small intestinal epithelial cells.

MicroRNA -7-5p regulates the proliferation and migration of intestinal epithelial cells by targeting trefoil factor 3 via inhibiting the phosphoinositide 3 - kinase / Akt signalling pathway.

Studies have found a high - fat diet destroys gut microbiota, reduces the production of epithelial cells lining the intestine and causes gut bacteria to invade intestinal epithelial cells.

The effects of consuming emulsifiers were eliminated in mice devoid of microbiota (germ - free mice), and transplanting microbiota from emulsifier - treated mice to germ - free mice was sufficient to transfer alterations in intestinal epithelial cells» homeostasis, suggesting a central role played by the microbiota in tumor development.

This study demonstrated that emulsifier - induced alterations in the microbiome were necessary and sufficient to drive alterations in intestinal epithelial cells» homeostasis, which is thought to govern tumor development.

Researchers from the University of Michigan and the Mayo Clinic studied rat IEC - 6 intestinal epithelial cells, chosen because they maintain a stable diploid genomic structure (two sets of chromosomes), lack the cellular characteristics of cancer cells, and replicate normally.

They concluded that macrophages are a main source of IL - 10 in the wound bed, and IL - 10 stimulates in vitro intestinal epithelial wound healing and increases in expression during in vivo intestinal epithelial wound repair.

The research team, led by Georgia State University and the University of Michigan, wanted to understand how a wound heals in the intestine because in IBD, which includes Crohn's disease and ulcerative colitis, damage to the intestinal epithelial barrier allows bacteria in the intestine to go across the barrier and stimulate the body's immune system.

The team also analyzed the effects of IL - 10 on epithelial wound closure in vitro using an intestinal epithelial cell line.

They found IL - 10 promotes intestinal epithelial wound repair through the activation of cAMP response element - binding protein (CREB) signaling at the sites of injury, followed by synthesis and secretion of the WNT1 - inducible signaling protein 1 (WISP - 1).

In this study, the researchers found that a specific population of immune cells called macrophages have the ability to secrete or produce a protective or healing factor known as Interleukin - 10 (IL - 10), which can interact with receptors on intestinal epithelial cells to promote wound healing.

While abnormal immune responses are largely responsible for these diseases, issues relating to gut microbiome, intestinal epithelial cells, immune components and the gut's rhythmic peristalsis motions can also contribute to and exacerbate symptoms.

«Chronic inflammation of the intestine is thought to be caused by abnormal interactions between gut microbes, intestinal epithelial cells and the immune system, but so far it has been impossible to determine how each of these factors contribute to the development of intestinal bowel disease,» said Hyun Jung Kim, Ph.D., former Wyss Technology Development Fellow and first author on the study, speaking about the limitations of conventional in vitro and animal models of bacterial overgrowth and inflammation of the intestines.

A 2012 study found that consuming maltodextrin increased bacterial adhesion to human intestinal epithelial cells and enhanced E. coli adhesion, which is associated with autoimmune disorders and dybiosis in your gut.

Not exact matches

The strict definition of celiac disease — positive antibodies to gliadin, intestinal endomysium, and tissue transglutaminase, together with the presence of HLA - DQ2 or HLA - DQ8 genes and an intestinal biopsy that shows at least 20 - 25 CD3 cells per 100 epithelial cells — will account for about 75 - 80 % of all those sensitive to gluten.

Efficient repair of the epithelial barrier is critical for suppressing inflammation and reestablishing intestinal homeostasis.