However, two main triggers have been identified to produce zonulin and are thought to contribute to increases
in intestinal hyperpermeability in everyone who has a gut wall, not just people with autoimmune disease.
Dysbiosis is also the foundation for a syndrome that is at least involved with or possibly the cause of all those gut disorders to greater or lesser degrees — leaky gut syndrome or
intestinal hyperpermeability aka intestinal tight junction malfunction.
The authors of a 1999 paper published in the Journal of Parenteral and Enteral Nutrition studied the effects of glutamine supplementation
on intestinal hyperpermeability (leaky gut) in a group of patients with Crohn's disease.
The scientific name for leaky gut syndrome is
intestinal hyperpermeability, which essentially translates to «an excessively permeable intestinal lining.»
Digestive enzymes also play a key role in gastrointestinal health because they can exert a powerful effect in addressing a full range of commonly recognized gastrointestinal disturbances, including intestinal irritation, maldigestion, malabsorption,
intestinal hyperpermeability, gut dysbiosis, and food allergies and sensitivities.