«Because the primary Small
Intestine Chip recapitulates the physical microenvironment that
cells experience inside the human
body, such as fluid flow and cyclic peristalsis - like stretching motions, it exhibits a genome - wide gene expression profile that comes closer to its
in vivo counterpart
than that of the same intestinal
cells grown as 3D organoids,» said first - author Magdalena Kasendra, Ph.D., a former Postdoctoral Fellow on Ingber's team and now Principal Scientist at Emulate, Inc.
in Boston.
A healthy human
body carries over 100 trillion microorganisms
in the
intestines, which is ten times greater
than the total number of human
cells in the
body.