When these cells are transplanted
into animal brains, they survive, and turn into the correct type of brain cell.
Once this was accomplished, they noticed the cells didn't function when transplanted
into animal brains.
Researchers had experimented before with injecting blood
into animal brains, to mimic a hemorrhage, and had indeed observed the onset of hydrocephalus.
Not exact matches
«Our
brains are hard - wired to get us
into investing trouble; humans are pattern - seeking
animals... Our
brains are designed to perceive trends even where they might not exist.
I saw an
Animal Planet program last year about a toddler who ingested raccoon roundworm eggs at a playground and almost died as the larva went
into his
brain, ate through his -LSB-...]
The pair noticed that certain parts of the
animal brain were inherently sensitive to repetition — regardless of whether it translated
into a valued juice reward.
And when the team injected antibody - treated cells
into mouse
brains, the
animals showed no symptoms at all, whereas
animals injected with prion - infected, but untreated, cells died after about 160 days.
When injected
into mice engineered with a tau mutation that makes the protein clump abnormally in
brain cells, triggering memory and motor problems, the antibodies reduced the clumping and improved the
animals» behavior.
So he implanted various human tumors — including ovarian, breast, colon, liver, and
brain —
into mice and then injected the
animals with antibodies that disable CD47.
In 1885 German biologist Paul Ehrlich (best known for curing syphilis) discovered that if he injected a dye
into the abdomen of
animals, he could color all their organs — all except the
brain.
The researchers have now provided further evidence for this new theory by showing that the abnormal protein coded for this genetic disorder can be transmitted to normal
animals by the injection of diseased cells
into their
brain.
Instincts such as mating or fighting are innate behaviors generally thought to be hardwired
into an
animal's
brain.
Chen agrees: He said his experiment «carries much less risk of creating
animals with greater «
brain power» than normal» because the human organoid goes
into «a specific region of already developed
brain.»
One concern raised by the human
brain organoid implants «is that functional integration [of the organoids]
into the central nervous system of
animals can in principle alter an
animal's behavior or needs,» said bioethicist Jonathan Kimmelman of McGill University in Montreal.
A few microscopic techniques can focus light deep
into the intact
brains of dead
animals to study its structure without damaging the axons, but much of this light is scattered away by the fatty lipid membranes that surround individual cells, making the technique less than perfect.
The best microscopes currently available can detect light from 3 to 4 millimetres
into the
brain, enough to see light signals coming from the cortex of a small
animal, but not enough to see deep - seated structures such as the hippocampus.
Then, instead of sending neural signals from the
animal's
brain to a robot, he shunts them back
into the muscles of the paralyzed arm, thereby bypassing the spinal cord.
Injected
into mice, synthetic prions punch tiny holes in
brain tissue (right), compared with healthy
animals (left).
Dissecting the
animals»
brains, he and his colleagues extracted tissue and injected it
into the
brains of healthy
animals.
Ultrasound focused within the skull can trigger movement in
animals — could it give us a safe way to plug technology
into the
brain?
By reversibly deactivating the new nerve fibers that grow, the neurobiologists were ultimately able to demonstrate for the first time that a group of these fibers is essential for the recovery of the motor function observed: Nerve fibers that grew
into the spinal cord from the intact front half of the
brain — changing sides — can reconnect the spinal cord circuits of the rats» paralyzed limbs to the
brain, enabling the
animals to grip again.
In one such approach, researchers surgically remove
brain cells, use viruses to transfer genes to the cells, and then graft them back
into the
animal's
brain tissue.
Earlier
animal studies have shown that A-beta can move
into the
brain if it's injected
into the bloodstream, but scientists didn't know whether A-beta from the blood can be plentiful enough to form plaques in the
brain.
A subset of the implanted human stem cells matured
into rotund, humanlike astrocytes in the
animals»
brains, taking over operations from the native mouse astrocytes.
In a lab near Deisseroth's office, Tye inserted a fiber - optic cable
into a mouse's little
brain at just the right spot, leaving enough slack for the
animal to run around.
I wonder if the «uncanny valley», the discomfort experienced when confronted by a human - like android (12 January, p 35), could be related to the idea that our
brains organise things
into specific categories, such as dogs and fish under
animals (5 January, p 10)?
On the other hand, the problem is, you know, with embryonic stem cells, they haven't been able to get stem cell lines from livestock
animals that can proliferate in that way, without just sort of veering up in their own direction and turning
into, instead of muscle, turning
into brain tissue or bone tissue or something else.
While previous investigations
into the protein's effects have used either mice in which gene expression was knocked out or transgenic
animals that expressed human gene variants throughout their lifetimes, the MGH - MIND - led study used a different approach to investigate the effects of introducing the variant forms of the protein
into brains in which plaque formation had already begun.
The results, published in May in Current Biology, suggest systems in one side of the
brain remain active as people venture
into unfamiliar sleep situations — an apparent survival strategy reminiscent of the unihemispheric sleep reported in certain
animals.
The out - of - place organs extended information - transmitting nerve fibers known as axons
into the
animal's
brain.
Rodents learn to put their heads under a microscope as a daily routine, letting researchers peer
into their
brains while the
animals are relaxed and happy
This research offers key insights
into how
brain activity is shaped and refined as
animals learn to repeat behaviors that evoke a feeling of pleasure.
In his new book Why Humans Like to Cry, neurologist Trimble delves
into how evolution and culture seemingly shaped the human
brain to express emotion on a higher level than the rest of the
animal kingdom.
Their findings suggest that even the earliest
animals had the makings of both vertebrate and invertebrate visual systems, and that some of the photoreceptor cells in the invertebrate
brain were transformed through a series of steps
into vertebrate eyes.
«Dolphins evolved from relatively small -
brained animals like cows and hippos
into this large -
brained, highly specialized aquatic organism,» says Caro - Beth Stewart, an evolutionary biologist at the State University of New York, Albany, who was not involved in the research.
If lamprey software can help people with spinal injuries, it will be in the shape of
animal brain circuitry realised on a chip wired
into a human being — a kind of cyborg sandwich.
The emerald cockroach wasp, for example, transforms its formidable targets — cockroaches many times its size —
into complacent meals for the wasps» hungry offspring by manipulating the
animals»
brain chemistry.
He added that the existence of episodic memory in lower
animals has implications for research on human diseases that affect memory, including Alzheimer's, Parkinson's and Huntington's diseases, since the majority of research on the
brain — and the drugs used to treat memory diseases and dementia — start out based on insights
into how the
brain works in rats.
Patrik Verstreken: «Our research
into brain diseases is not possible without
animal models.
The U.C. San Francisco team had previously shown that upping levels of GDNF
into a part of the
brain associated with drug addiction (the ventral tegmental area) dramatically curtailed the
animals» habits.
In the late 1970s, while at the University of Utah, Olivera's students Craig Clark and Michael McIntosh tried injecting the cone snail venom directly
into the
brains of mice and discovered that different components of venom changed the
animals» behavior.
Because the molecule must be injected
into the
brain, this kind of chemical - based fMRI won't be applied to humans anytime soon, says Jasanoff, but it could be used to probe addiction and disease using
animals.
According to research published online in August in Nature Neuroscience, the mammalian
brain seems to do the same, collapsing the world
into a flat plane even as the
animal skitters up trees and slips deep
into burrows.
To find out whether the virus could help treat cancer in a living
animal, the researchers injected either Zika virus or saltwater (a placebo) directly
into the
brain tumors of 18 and 15 mice, respectively.
In rodents, toxo's natural hosts, the parasite gets
into the
brain and makes the
animals less fearful, resulting in them taking more risks.
Read previous Zoologger columns: The only males with more
brain than females, How a blurry - eyed spider pounces on target, Gecko's amputated tail has life of its own, Unique life form is half plant, half
animal, Transgender fish perform reverse sex flip, My
brain's so big it spills
into my legs, Dozy hamsters reverse the ageing process, To kill a mockingbird?
A decade ago, these similarities prompted neuroscientist Mathias Jucker at the University of Tübingen in Germany to test whether injecting
brain extracts containing misfolded amyloid - β
into mice could seed an abnormal build - up of amyloid in the
animals»
brains.
It cause
animal brains to turn
into a spongy mess in scrapie, a disease of sheep, and in bovine spongiform encephalopathy (BSE or «mad cow disease»), as well as in human prion diseases such as CJD.
Some worry that such human cells, when combined with
animal embryos, could develop
into brain cells, sperm, or egg cells in the chimeric offspring.
When Hayashi injected a mutant gene for PAK
into mouse embryos and later killed the adult mice and dissected and examined their
brains, she discovered that the
animals» dendritic spines — branched stalks that receive input from neighboring neurons — were short, fat, and sparse.