Sentences with phrase «into apoptosis»

When BubR1H / H; INK - ATTAC mouse bone marrow cells were pushed into senescence in vitro by the PPAR - γ - activating drug rosiglitazone, a subpopulation of the cells exhibited high levels of INK - ATTAC expression and GFP, coupled with SAβ - gal staining; subsequent to treatment with the INK - ATTAC activating drug, these cells rapidly entered into apoptosis, and within 48 h were either destroyed or in the cell death process.

«In modern biology mitochondria are considered to be much more than the powerhouse of the cell; they integrate multiple intracellular signals to regulate progression through the cell cycle and into apoptosis.

Not exact matches

However, in developing brain cells, the researchers found TLR3 activation also influences 41 genes that add up to a double whammy in this model — diminished stem cell differentiation into brain cells and increased cell suicide, a carefully controlled process known as apoptosis.

By invigorating the mitochondria, SIRT3 and SIRT4 extend the life of cells, by preventing flagging mitochondria from developing tiny holes (or pores) in their membranes that allow proteins that trigger apoptosis, or cell death, to seep out into the rest of the cell.

Injections of iPSC - EPCs did not however have significant effect on tumor growth or on overall survival, but transducing cells with a baculovirus expressing CD40L, a member of the TNF gene family which can induce apoptosis [6, 7], and injection into the breast cancer lung metastasis, increased levels of pro-apoptotic cytokines in lung tissues, indicating the induction of apoptosis by CD40L carried by the EPCs (See figure).

In this case, the trigger is a drug that interacts with the protein produced by the «suicide gene,» which metabolizes it into a form deadly to the cell, causing it to commit programmed cell death (apoptosis).

Given the apoptosome's critical role in the execution of stress - induced apoptosis, these studies provide key insights into the mechanisms by which many, if not most, chemotherapeutic agents induce cell death.

Manuscripts that increase our understanding of the processes through which stem cells and progenitors differentiate into committed progeny, the commitment cell death programs such as apoptosis and necrosis, aging, and the transition between proliferation and cell cycle arrest are welcome.

When introduced into the MDA - MB - 231 cells, the Δ2A mutant did not induce apoptosis of these cells whereas WT LARP7 readily impaired cell survival, supporting the model that the ability of LARP7 to assemble 7SK snRNP and suppress P - TEFb is necessary for its tumor suppressor potential.

Walnuts and pecans contain ellagic tannins, which the gut transforms into ellagic acid, which converts a cancer cell back into fat - burning, which reactivates the P53 gene, which causes the cell to commit apoptosis.

Converting cancer cells into programmed apoptosis is characteristic of most natural alternative methods of killing cancer cells.

A mesenchymal stem cell is a primitive cell with the ability to self - replicate, reduce inflammation, fight apoptosis, and differentiate into multiple tissues.