As we discussed in a previous episode of HPAY, antibiotics and their devastating cousins the «HIV antiretrovirals» take
us into bacterial resistance and dependence on ever more powerful drugs.
Not exact matches
If so, and if researchers can identify the exact sugars responsible, those molecules might be converted
into desperately needed new antibiotic drugs that could sidestep some of the problems, such as
bacterial resistance, with existing antibiotics.
A plasmid, a simple kind of DNA - delivery vehicle, will move a gene for antibiotic
resistance into the
bacterial cells, jump - starting the Crispr - Cas9 system.
Bacteria expressing enzyme in one cell (bright green), while genetically identical cells do not, remaining protected from antibiotic onslaught; image courtesy of Yuichi Wakamoto / Neeraj Dhar / John McKinney Some strains of nasty
bacterial infections, such as MRSA (methicillin - resistant Staphylococcus aureus), come loaded with
resistance to antibiotics built right
into their genes.
The team cut and pasted a bovine gene for NRAMP1, a protein linked to
resistance against TB and other
bacterial infections,
into fetal dairy cow genomes.
Ongoing studies are identifying commensal
bacterial species that can be developed
into next - generation probiotics to reestablish or enhance colonization
resistance.
Cheng's group previously developed short protein chains that twist
into a helical spiral, giving them a stiff, rodlike structure that can punch holes through
bacterial membranes — a method of killing to which bacteria have little ability to develop
resistance.
«This discovery sets up the possibility of introducing FLS3
into other economically important crop plants, which might provide
resistance to
bacterial pathogens that is not naturally present in other plants.»
Her work has led to a number of seminal discoveries and insights
into pathways governing antibiotic
resistance and virulence of
bacterial pathogens.