Zheng, together with Leah Boyer, then a researcher in Gage's lab and now director of Salk's Stem Cell Core, generated diseased neurons by taking skin cells from patients with Leigh syndrome, reprogramming them into stem cells in culture and then coaxing them to develop
into brain cells in a dish.
«We're looking at bacteria that make magnetic nanoparticles, so we can insert their genes
into brain cells in the same way,» Pralle says.
Not exact matches
The building block electronic and protonic actual occasions are,
in the case of human beings, swept
into vastly more complex, Chinese box - like sets of containing societies within which there are social levels that can be identified with
cells, others which answer to Aristotle's levels of tissues and organs, and which finally are presided over by what Whitehead refers to as the regnant nexus, a social thread of complex temporal inheritance which, Whitehead suggests, wanders from part to part of the
brain, is the seat of conscious direction of the organism as a whole, and answers to what
in Plato and Aristotle is called the soul.
Any form of hurrying you
into the birth process or, once
into it, hurrying the process faster than it goes naturally will damage
cells in the baby's
brain.
The
cells from baby are
in Mom's
brain and the
cells from Mom cross
into baby through her placenta.
Stem
cells have also been identified
in human milk, and have the potential to differentiate
into mammary epithelial lineages under mammary differentiation conditions
in vitro, as well as other
cell types
in corresponding microenvironments, including bone
cells,
brain cells, liver
cells, pancreatic beta
cells and heart
cells.
Docosahexaenoic acid is incorporated
in large amounts
into cell membranes of the developing retina and
brain.
She demonstrated that early experience leads to lasting changes
in the molecular structure of the
brain and discovered a gene involved
in the spread of
brain cancer
cells into healthy
brain tissue.
In the direct reprogramming, the researchers exposed the adult skin
cells to a specific mix of signaling molecules the scientists» past research had found would convert healthy skin
cells directly
into a type of
brain cell called medium spiny neurons, without intermediate steps along the way.
Another gene, PCDH15, plays a role
in the hair
cells» ability to convert sound
into brain signals (Molecular Psychiatry, DOI: 10.1038 / MP.2014.8).
Crayfish have a «nursery»
in their heads where blood
cells transform
into neurons — the process may one day help us to regenerate our own
brain cells
As the cochlea's fluid moves, about 15,000 hair
cells sitting
in it, each tuned to a particular frequency, pick up the motions; the cochlear nerve translates the movements
into auditory messages that are sent to the
brain.
When injected
into mice engineered with a tau mutation that makes the protein clump abnormally
in brain cells, triggering memory and motor problems, the antibodies reduced the clumping and improved the animals» behavior.
Scores of laboratories at universities and
in private industry are uncovering how to use these
cells, which transform
into neurons, astrocytes (the
cells that regulate transmission of electrical impulses
in the
brain) and oligodendrocytes (which insulate nerve fibers with a fatty coating).
In the past decade, a handful of discoveries have unleashed a flood of research
into ways neural stem
cells can be used for treating degenerative
brain disorders and for
brain repair.
The lack of these genes
in the neurons of active mice suggested that their
brain cells did not immediately leap
into an excited state
in response to the stressor.
When the researchers tracked the stem
cells in the mice's
brains, they saw that only about 5 percent of them actually developed
into neurons, suggesting the
cells did not rescue memory by replacing dead neurons, LaFerla says.
Soon after lung cancer
cells (
in green) spread
into the
brain, extracellular matrix molecules (
in red) can shield them from the hostile surroundings.
In a separate but related study, scientists this week also announced that they successfully reversed Parkinson - like symptoms in several monkeys by transplanting human neural stem cells into their brain
In a separate but related study, scientists this week also announced that they successfully reversed Parkinson - like symptoms
in several monkeys by transplanting human neural stem cells into their brain
in several monkeys by transplanting human neural stem
cells into their
brains.
«We now know much more about how the
cells work and how they best become integrated
into the circuits
in the
brain.»
Published
in the February 27 issue of
Cell, the study found that tumor
cells that reach the
brain — and successfully grow
into new tumors — hug capillaries and express specific proteins that overcome the
brain's natural defense against metastatic invasion.
But scientists are making progress
in refining these therapies, and the first ever trial of fetal stem
cells injected directly
into the
brain is currently under way
in children with Batten disease, a rare and fatal illness of the nervous system.
The
cells, taken from the
brain via the nose, have been coaxed
into becoming insulin factories
in the rat pancreas
The new findings prove that a group of
cells in the
brain can turn a short - lived sensation
into complex, long - lasting muscle movements, says physiologist Simon Alford of Northwestern University.
The first step
in the process involves inserting
into those
brain cells a gene that makes a light - sensitive protein.
«For these
cell - level «rules» to be translated
into specific
brain proportions, we would also expect to see these rules reflected
in predictable growth patterns of the mammalian
brain, particularly
in species from the same group of mammals,» she said.
The researchers tinkered with the voltage
in cell membranes of developing African clawed frogs (Xenopus laevis) and found that electric charge plays a role
in how big the
brain grows and what kind of tissue developing
cells grow
into.
In this study, Cherqui's team transplanted wildtype HSPCs into an FA mouse model, reporting that the HSPCs engrafted and soon differentiated into macrophages in key regions of the mice's brain and spinal cord where they appeared to transfer wildtype FXN into deficient neurons and muscle cell
In this study, Cherqui's team transplanted wildtype HSPCs
into an FA mouse model, reporting that the HSPCs engrafted and soon differentiated
into macrophages
in key regions of the mice's brain and spinal cord where they appeared to transfer wildtype FXN into deficient neurons and muscle cell
in key regions of the mice's
brain and spinal cord where they appeared to transfer wildtype FXN
into deficient neurons and muscle
cells.
In newborn mammals, the SVZ is the biggest depot for the precursor
cells that migrate to populate various
brain regions, and differentiate
into multiple
cell types.
«Disturbances to these processes may cause neuronal stem
cells to develop
into different types of
cells or may cause neurons to migrate to different locations
in the
brain, changing neuronal circuitry and potentially leading to behavioral disorders like schizophrenia.»
Nevertheless,» [the] study is very important because it demonstrates for the first time that we can use gene therapy to transform
cells in the
brain into ones that will secrete GDNF,» says Jeffrey Kordower, a professor of neurological sciences at Rush Presbyterian Medical Center
in Chicago.
In one such approach, researchers surgically remove
brain cells, use viruses to transfer genes to the
cells, and then graft them back
into the animal's
brain tissue.
The team used human embryonic stem
cells — which can transform
into any
cell of the body — and cultured them
in a mixture of chemicals to grow human
brain cells.
In the Cell Stem Cell study, Zhiheng Xu of the Chinese Academy of Sciences in Beijing sidestepped the mice's natural resistance to Zika virus by injecting a Samoan isolate directly into fetal brain
In the
Cell Stem
Cell study, Zhiheng Xu of the Chinese Academy of Sciences
in Beijing sidestepped the mice's natural resistance to Zika virus by injecting a Samoan isolate directly into fetal brain
in Beijing sidestepped the mice's natural resistance to Zika virus by injecting a Samoan isolate directly
into fetal
brains.
In «Diabetic rats cured with their own stem cells ``, we report how researchers cured diabetic rats by turning brain stem cells extracted through the nose into insulin - producing cells in the pancrea
In «Diabetic rats cured with their own stem
cells ``, we report how researchers cured diabetic rats by turning
brain stem
cells extracted through the nose
into insulin - producing
cells in the pancrea
in the pancreas.
In the depths of the mind, networks of
brain cells perform a sublime symphony, and a twinkle of insight pops
into consciousness.
The
cells that make up the walls of blood capillaries are joined together more tightly
in the
brain than elsewhere
in the body, preventing proteins and
cells getting
into the
brain.
A subset of the implanted human stem
cells matured
into rotund, humanlike astrocytes
in the animals»
brains, taking over operations from the native mouse astrocytes.
Scientists are hopeful that ultimately these
cells could be transformed
in the laboratory to yield specific
cell types needed for a particular treatment, or to cross the «blood -
brain barrier» by expressing specific therapeutic agents that are released directly
into the
brain.
The
brain is protected by a barrier of
cells that tightly regulates the transport of substances
into this organ
in order to prevent infection.
A group of really brainy scientists have moved closer to growing «therapeutic»
brain cells in the laboratory that can be re-integrated back
into patients»
brains to treat a wide range of neurological conditions.
Affecting the central nervous system, it causes neonatal meningitis by multiplying
in immune
cells, such as macrophages, and then disseminating
into the bloodstream to subsequently invade the blood -
brain barrier.
However, occasionally germ
cells can get trapped
in the wrong part of the body during development and may later turn
into brain tumours, for example.
According to tradition
in neuroscience,
brain cells fall
into two broad groups — neurons and glial
cells.
The recipe, described
in Nature, allows human pluripotent stem
cells to spontaneously attempt to assemble
into a tiny approximation of a whole
brain by making whatever
brain structures the stem
cells choose.
In the present study, her team took skin cells from patients with lissencephaly and turned them into iPS cells, which they then cultivated under special conditions into neuronal stem cells and neurons that are copies of those in the patients» brain
In the present study, her team took skin
cells from patients with lissencephaly and turned them
into iPS
cells, which they then cultivated under special conditions
into neuronal stem
cells and neurons that are copies of those
in the patients» brain
in the patients»
brains.
A 2010 study
in Stem
Cells and Development showed that fetal cells can migrate to the brain of a mother mouse and mature into neurons, Nelson
Cells and Development showed that fetal
cells can migrate to the brain of a mother mouse and mature into neurons, Nelson
cells can migrate to the
brain of a mother mouse and mature
into neurons, Nelson says.
We not only introduced the gene
into specific
brain regions of the mouse, but we could also direct it to specific
cell types to test which ones played a role
in regulating sociability.»
These rare, damage - repairing
cells are found
in many organs (including the
brain), but the
cells can transform
into only a limited range of
cell types.
According to his unpublished findings, when he puts glioblastoma
cells from patients
into lab dishes with
brain organoids, the
cells attach to the surface of the organoids, burrow
into them, and within 24 to 48 hours grow
into a mass that eventually «looks exactly like what happened
in the patient's own
brain,» Fine said.