Sentences with phrase «into brain stem cells»

Not exact matches

Stem cells have also been identified in human milk, and have the potential to differentiate into mammary epithelial lineages under mammary differentiation conditions in vitro, as well as other cell types in corresponding microenvironments, including bone cells, brain cells, liver cells, pancreatic beta cells and heart cells.

Researchers chemically reprogrammed human stem cells into small bundles of functional brain cells that mimic the developing brain.

The virus does this because, unlike most microbes, Zika can pass from blood into the brain, where it infects and kills stem cells, having severe effects on developing brains.

In the past decade, a handful of discoveries have unleashed a flood of research into ways neural stem cells can be used for treating degenerative brain disorders and for brain repair.

When the researchers tracked the stem cells in the mice's brains, they saw that only about 5 percent of them actually developed into neurons, suggesting the cells did not rescue memory by replacing dead neurons, LaFerla says.

In a separate but related study, scientists this week also announced that they successfully reversed Parkinson - like symptoms in several monkeys by transplanting human neural stem cells into their brains.

Curiously, the researchers discovered that only about five percent of the stem cells injected into the brain - addled mice matured into adult neurons.

But scientists are making progress in refining these therapies, and the first ever trial of fetal stem cells injected directly into the brain is currently under way in children with Batten disease, a rare and fatal illness of the nervous system.

If you put embryonic stem cells on a substrate like Jell - O — mechanically similar to brain tissue — they turn into neurons.

Scientists headed by Dr. Stevens Rehen differentiated human induced pluripotent stem (iPS) cells into neural stem cells and into further complex tridimensional structures, known as neurospheres and brain organoids.

Those issues emerged 17 years ago, when a Stanford colleague of Greely's proposed implanting human stem cells into mouse brains to see what would happen when the former turned into neurons; the experiment has not yet happened.

«Disturbances to these processes may cause neuronal stem cells to develop into different types of cells or may cause neurons to migrate to different locations in the brain, changing neuronal circuitry and potentially leading to behavioral disorders like schizophrenia.»

They then encouraged the stem cells to grow into neurons, a type of brain cell.

The team used human embryonic stem cells — which can transform into any cell of the body — and cultured them in a mixture of chemicals to grow human brain cells.

In the Cell Stem Cell study, Zhiheng Xu of the Chinese Academy of Sciences in Beijing sidestepped the mice's natural resistance to Zika virus by injecting a Samoan isolate directly into fetal brains.

In «Diabetic rats cured with their own stem cells ``, we report how researchers cured diabetic rats by turning brain stem cells extracted through the nose into insulin - producing cells in the pancreas.

A subset of the implanted human stem cells matured into rotund, humanlike astrocytes in the animals» brains, taking over operations from the native mouse astrocytes.

Zheng, together with Leah Boyer, then a researcher in Gage's lab and now director of Salk's Stem Cell Core, generated diseased neurons by taking skin cells from patients with Leigh syndrome, reprogramming them into stem cells in culture and then coaxing them to develop into brain cells in a dStem Cell Core, generated diseased neurons by taking skin cells from patients with Leigh syndrome, reprogramming them into stem cells in culture and then coaxing them to develop into brain cells in a dstem cells in culture and then coaxing them to develop into brain cells in a dish.

Johns Hopkins researchers have developed a method to efficiently turn human stem cells into retinal ganglion cells, the type of nerve cells located within the retina that transmit visual signals from the eye to the brain.

The recipe, described in Nature, allows human pluripotent stem cells to spontaneously attempt to assemble into a tiny approximation of a whole brain by making whatever brain structures the stem cells choose.

In the present study, her team took skin cells from patients with lissencephaly and turned them into iPS cells, which they then cultivated under special conditions into neuronal stem cells and neurons that are copies of those in the patients» brains.

«We putzed around and tried different things,» he said, and after some false starts — they weren't using quite the right brain - making ingredients, so the stem cells developed into micro-pancreases and colons — it worked.

A 2010 study in Stem Cells and Development showed that fetal cells can migrate to the brain of a mother mouse and mature into neurons, Nelson Cells and Development showed that fetal cells can migrate to the brain of a mother mouse and mature into neurons, Nelson cells can migrate to the brain of a mother mouse and mature into neurons, Nelson says.

Novitch's UCLA lab group has likewise used its brain organoids to pinpoint additional receptors by which the virus may gain entry into neural stem cells, and identified a few other drug leads for blocking infection.

The researchers implanted stem cells from mouse embryos into the brains of rats and mice whose dopamine - producing neurons had been obliterated by a toxin.

Another is that the transplanted bits of tumor act nothing like cancers in actual human brains, Fine and colleagues reported in 2006: Real - life glioblastomas grow and spread and resist treatment because they contain what are called tumor stem cells, but tumor stem cells don't grow well in the lab, so they don't get transplanted into those mouse brains.

On the other hand, the problem is, you know, with embryonic stem cells, they haven't been able to get stem cell lines from livestock animals that can proliferate in that way, without just sort of veering up in their own direction and turning into, instead of muscle, turning into brain tissue or bone tissue or something else.

Various reports in recent years have claimed that stem cells from one tissue — for example, blood — can mature into other tissues such as muscle or brain.

Scientists at Columbia's Zuckerman Institute have uncovered new insights into how stem cells transform into brain cells that control leg movements.

Human fetal stem cells injected into the brains of vervet monkeys may help treat the simian equivalent of Parkinson's, says Eugene Redmond of Yale University.

Stem cells hold tremendous promise for medicine; their ability to metamorphose into other kinds of cells make them useful for repairing injuries — from heart attacks to brain damage.

To replicate these cell culture results, Rani used human stem cells to grow neurons into what is called a mini brain.

All formed the same types of stem cells, which give rise to «progenitor» cells that, in turn, divide into neurons and eventually organize themselves in six layers of brain tissue.

With a bit of persuasion they can be transformed into pluripotent stem cells capable of developing into all manner of tissues, from bone to blood to brain.

In a study spanning molecular genetics, stem cells and the sciences of both brain and behavior, researchers at University of California San Diego, with colleagues at the Salk Institute of Biological Studies and elsewhere, have created a neurodevelopmental model of a rare genetic disorder that may provide new insights into the underlying neurobiology of the human social brain.

Normally, adult stem cells can only morph into the type of tissue in which they reside, such as blood, brain or muscle.

From there, researchers can prompt the stem cells to turn into brain cells for further study.

The scientists collected skin cells from 19 people, aged from birth to 89, and prompted them to turn into brain cells using both the induced pluripotent stem cell technique and the direct conversion approach.

Most of these trials involve stem cell - derived neural progenitor cells, which can turn into several different types of brain or spinal cord cells, or oligodendrocyte progenitor cells, which create the myelin sheaths that insulate and protect nerve cells.

Neuroscientists Jing Wang and Freda Miller, both then at Toronto's Hospital for Sick Children, showed that when nondiabetic mice are given metformin, their memory improves, thanks to an increase in the neural stem cell population and in the number of these cells that develop into healthy neurons in the hippocampus, the brain's memory center.

McKay announced that he had mitigated the symptoms of Parkinson's in rats by using mouse embryonic stem cells that he had turned into dopamine - producing brain cells.

But at the end of the first year, the team examined the brains of half the monkeys and found that the stem cells had turned into dopamine - releasing cells.

«The blood - brain barrier forms pretty early in gestation, so the thyroid hormone, even from the mother, is probably not getting through the barrier and into the brain, likely leading to developmental deficits,» says Shusta, whose group was among the first to develop blood - brain barriers from patient - derived stem cells in the lab dish.

THE GREAT DIVIDE Young brain stem cells (one shown dividing, left) pack old proteins tagged with ubiquitin (red) into one daughter cell.

To grow larger brains, the stem cells would also have to differentiate into blood vessels to supply nutrients to the growing organoid.

«By activating TLR3, the Zika virus blocks genes that tell stem cells to develop into the various parts of the brain.

After concluding that increased stem cell production in a certain area of the brain had a positive effect on behavioral deficits of Alzheimer's, Prof. Offen has moved to research into the area of the brain that controls memory.

In turn, hyper - activated TLR3 turns off genes that stem cells need to specialize into brain cells and turns on genes that trigger cell suicide.

However, in developing brain cells, the researchers found TLR3 activation also influences 41 genes that add up to a double whammy in this model — diminished stem cell differentiation into brain cells and increased cell suicide, a carefully controlled process known as apoptosis.

Several years ago, one of the students in Verma's lab noticed that BRCA1 is very active in the neuroectoderm, a sliver of embryonic tissue containing neural stem cells that divide and differentiate into the brain's vast assortment of cell types and structures.