They pick up fluorescent signals from particles inserted
into cells and tissues that are illuminated with specific wavelengths of light.
Not exact matches
Instead of being injected
into the bloodstream
and exposed to the rest of the body's
tissue — with all the unpleasant side effects, as is the case with chemotherapy — these agents only target cancer
cells.
The printers start with
cells of the desired
tissue and combine them with a powdery «ink,» which is molded
into the required shape.
ReInnervate, a start - up in Durham, England, is developing a tiny, three - dimensional plastic scaffolding on which human
cells can be grown
into artificial
tissue,
and perhaps eventually
into replacements for organs.
Animal
cells are cultured from stem
cells and incubated in a «bioreactor»
into tissue that can be «harvested»
and formed
into familiar foods like meatballs, patties,
and fish sticks.
The building block electronic
and protonic actual occasions are, in the case of human beings, swept
into vastly more complex, Chinese box - like sets of containing societies within which there are social levels that can be identified with
cells, others which answer to Aristotle's levels of
tissues and organs,
and which finally are presided over by what Whitehead refers to as the regnant nexus, a social thread of complex temporal inheritance which, Whitehead suggests, wanders from part to part of the brain, is the seat of conscious direction of the organism as a whole,
and answers to what in Plato
and Aristotle is called the soul.
Such was the comfortable vista which, less than a century ago, began abruptly to change beneath our gaze, something in the fashion of those organic
tissues in the living body which, after long remaining harmless
and dormant, their
cells apparently indistinguishable from those of the surrounding
tissue, suddenly burst
into dangerous growth.
If the egg is fertilized by a sperm
cell, it stays in the uterus
and grows
into a baby, using that extra blood
and tissue to keep it healthy
and protected as it's developing.
Most other lubricants, freshening gels,
and massage oils on the market are hypo or hypertonic (too low or too high of a salt concentration compared with vaginal
tissues),
and cause water to be pushed
into, or pulled out of the vaginal
cells.
It's a rich source of stem
cells, particularly those that can grow
into tissues, organs,
and blood vessels.
She demonstrated that early experience leads to lasting changes in the molecular structure of the brain
and discovered a gene involved in the spread of brain cancer
cells into healthy brain
tissue.
To discover these targets, the team determined when
and where each gene is turned on or off in the
cells and tissues of H. contortus to reveal new insights
into the worm's lifecycle.
But as new methods of genetic modification emerge, both the scientific
and the sports communities are becoming increasingly aware that gene therapy — the insertion of genes
into an individual's
cells and tissues — will make its way onto the playing field.
Stomach switch The key to turning pluripotent stem
cells into stomach
cells was a pathway of interactions that acts as a switch between growing
tissues in the intestine
and in the antrum, a part of the stomach near its outlet to the small intestine.
Da Cruz
and his team grew replacement RPE
cells from human embryonic stem
cells on a thin plastic scaffold, before transplanting the
tissue into the back of each volunteer's eye.
Philippe Durand
and Marie - Hélène Perrard at the biotechnology company Kallistem in Lyon, France, say that their method coaxes seminiferous tubules —
tissue that produces sperm in the testes — taken from humans, rats or monkeys
into producing mature sperm
cells.
To develop their «disease in a dish» model, the team took skin
cells from patients with Allan - Herndon - Dudley syndrome
and reprogrammed them
into induced pluripotent stem
cells, which then can be developed
into any type of
tissue in the body.
EphA2 spreads cancer by allowing malignant
cells to migrate from the primary tumor
into circulation
and eventually to adhere to other
tissues.
International Stem
Cell scientists have converted them
into liver
cells and plan to convert them
into neurons for treating Parkinson's disease, pancreatic
cells for diabetes,
and other
tissues.
Cancer
cells can break away from a primary tumor, penetrate
into lymphatic
and blood vessels, circulate through the bloodstream,
and grow in a distant focus (metastasize) in normal
tissues elsewhere in the body.
Retinal
tissue contains light - sensitive
cells that absorb wavelengths in the visible spectrum
and convert them
into electrical signals.
Damaged mouse sciatic nerves produced hundreds of times the normal amount of two «chemoattractant» molecules, Cxcl1
and Cxcl2, which attach to the surfaces of neutrophils
and draw the immune
cells into injured
tissue.
To solve this problem, Smadar Cohen, a
tissue engineer at Ben - Gurion University of the Negev in Beersheba, Israel,
and colleagues seeded rat cardiac
cells onto scaffolds which they transplanted
into the omentums of eight rats.
The researchers — James Robl, a developmental biologist
and his colleagues at the University of Massachusetts at Amherst,
and Steve Stice at Advanced
Cell Technology in Worcester, Massachusetts — inserted a marker gene fused with a gene for resistance to the chemical neomycin
into a culture of connective
tissue cells called fibroblasts.
Compared with unheated mice, the animals with the faux fever had twice as many white blood
cells migrating out of the blood vessels
and into the lymph
tissue that lines the skin
and gut, which is where they need to be to attack incoming pathogens.
The researchers also found that arteries
and veins from the macaques» hearts grew
into the new heart
tissue, the first time it has been shown that blood vessels from a host animal will grow
into and nurture a large stem -
cell derived graft of this type.
Yoshiki Sasai at the RIKEN Center for Developmental Biology in Kobe, Japan,
and colleagues encouraged embryonic stem
cells to develop
into retinal
cells,
and then grew them alongside a protein matrix to promote the formation of
tissue.
They use a near - infrared laser beam, which can penetrate deep — in this context, deep means a centimeter or two —
into the
tissue, where a nanoparticle turns the near - infrared light
into blue light,
and that directs the activity of genetically engineered immune
cells.
Previous studies have found that brown fat can be coaxed
into action by activating the β3 - adrenergic receptor, which is expressed on the surfaces of brown
and white fat
cells, as well as on
cells of the urinary bladder
and other
tissues.
The real test will be to inject these
cells into mice
and see if they form teratomas — tumours containing
tissue or structures derived from all three germ layers.
«It has been shown in mice that live immune
cells in breast milk pass through the intestinal mucosa
into the blood circulation of the pups
and engraft in various
tissues,» says Hassiotou.
Dr Coleman
and her group have developed a sensitive test to allow them to detect the location
and number of the stem
cells after they've been added; they report that the stem
cells do not permanently integrate
into the host
tissue but instead produce signals that encourage the host's own
cells to heal the fracture more efficiently.
Reproductive
cells, such as an egg
and sperm, join to form stem
cells that can mature
into any
tissue type.
Finally, the team grew the
tissue in a three - dimensional system, which coaxed it
into forming all the structures found in gut
tissue, including the finger - like villi that protrude inwards to increase surface area,
and recesses called crypts containing the intestinal stem
cells that renew the gut lining weekly (Nature, DOI: 10.1038 / nature09691).
The researchers tinkered with the voltage in
cell membranes of developing African clawed frogs (Xenopus laevis)
and found that electric charge plays a role in how big the brain grows
and what kind of
tissue developing
cells grow
into.
Sen
and his colleagues tested sucralose, a popular low - calorie sweetener, on stem
cells —
cells that could change
into mature fat, muscle, cartilage or bone
cells — taken from human fat
tissue.
As it can take weeks to grow human
cells into intact differentiated
and functional
tissues within Organ Chips, such as those that mimic the lung
and intestine,
and researchers seek to understand how drugs, toxins or other perturbations alter
tissue structure
and function, the team at the Wyss Institute for Biologically Inspired Engineering led by Donald Ingber has been searching for ways to non-invasively monitor the health
and maturity of
cells cultured within these microfluidic devices over extended times.
The scientists» findings have wide implications in the effort to understand how organs are sculpted
into their shapes
and how
cells respond to their native mechanical environment both in healthy
tissues and during disease.
During embryonic development, undifferentiated stem
cells accumulate methyl groups
and other epigenetic marks that funnel them
into one of the three germ layers, each of which gives rise to a different set of adult
tissues.
To get
into the blood vessels, the
cell needs to penetrate
tissue, both when it leaves the tumour
and when it is attaching to a new organ.
In humans, the goal of SCNT is «nonreproductive cloning» — making embryos, then removing stem
cells from the embryo
and cultivating them to grow
into tissues that could cure diseases, replace organs
and heal injuries.
In one such approach, researchers surgically remove brain
cells, use viruses to transfer genes to the
cells,
and then graft them back
into the animal's brain
tissue.
These so - called pluripotent stem
cells can be derived from a variety of adult
cells and be guided
into almost any other
tissue type.
Researchers can create iPSCs from a patient's blood or skin
cells,
and use these patient - specific
cells to study diseases or even create new
tissues that could be transplanted back
into the patient as therapy.
The stem
cells used, mesenchymal stem
cells (MSCs), are thought to elicit a less vigorous immune reaction than blood stem
cells,
and MSCs can develop
into bone, along with other connective
tissues.
What's more, the researchers discovered two years ago that the suppression of Esrp activity helps to enable a process called the epithelial - mesenchymal transition (EMT), in which epithelial
cells acquire properties allowing them to detach
and develop
into new
tissue.
Stem
cells have the prized ability to divide
and replenish themselves, as well as turn
into different types of
tissues.
Labs could rejuvenate
cells from patients
and perhaps then grow them
into new
tissue that could repair parts worn out by old age or disease.
As the wound heals, the gel breaks down
into amino acids — the building blocks of proteins — that can be taken up by nearby
cells and used for
tissue repair, according to MIT neuroscientist Rutledge Ellis - Behnke.
With more - than -30-year-old frozen
tissues from a preserved frog, the team extracted
and implanted the nucleus of a dead
cell into a fresh host egg from a distantly related species.