The Human Biochemical Genetics Section studies selected biochemical defects and other genetic disorders to provide insight
into cellular mechanisms and to care for neglected groups of rare disease patients.
«Alcohol prevents ability to extinguish fearful memories in mice: Insight
into cellular mechanisms illuminates biological target for PTSD therapy.»
Not exact matches
Today is the 70th birthday of Elizabeth Hay, an embryologist at Harvard Medical School who, through pioneering studies on regeneration of amphibian limbs, has shed light on the
cellular mechanisms that transform normal cells
into tumors.
In addition, it provides a marker for cell fates and insight
into the molecular and
cellular mechanisms by which FSC progeny diverge
into distinct fates.
Researchers at Aarhus University, Denmark, have succeeded in identifying the
mechanisms involved in what is known as the acid pump, which at the
cellular level pumps acid
into the stomach — in some cases leading to gastric ulcers and gastroesophageal reflux disease.
They revealed that many of these exosomes contained ephrins and Ephs, and decoded the
cellular mechanism by which they were packed
into the exosomes.
A
cellular repair
mechanism attempts to rejoin the cut DNA ends, but occasionally inserts or deletes bases, which turns the DNA code
into gibberish and can knock out a targeted gene.
The findings add a new level of complexity to our understanding of the
cellular mechanisms of taste perception, which may ultimately lend insight
into individual differences in food preferences and dietary choices.
It supports proposals that use different technologies to build up knowledge of functional
mechanisms and intracellular dynamics with atomic structure information and integrate these
into an understanding of
cellular processes in the native environment and in real time.
Therefore, our findings could provide new insights
into an «old»
cellular defense
mechanism against invading viruses.»
The critical molecular and
cellular mechanisms that the T cells use to sense their environment and how this sensing is relayed
into a particular functional response are still unclear.
Additional
cellular analysis revealed a subset of these bacterial proteins that were secreted
into the host cytoplasm independent of the known Salmonella
mechanisms for transporting virulence proteins
into host cells
Now, a new study from University of Georgia
cellular biologists shows the
mechanism behind tubulin transport and its assembly
into cilia, including the first video imagery of the process.
Everon is a leader in understanding
cellular mechanisms of aging and translating this knowledge
into development of anti-aging therapies.
The underlying
mechanisms accounting for why hGDAsBMP are so much more beneficial in terms of neuroprotection and functional recovery than either hGDAsCNTF or undifferentiated precursor cells when transplanted
into spinal cord injured rats remain to be investigated, but it is likely that multiple
cellular functions are involved.
Recent advances in high - throughput molecular and
cellular profiling tools, particularly genome - wide transcriptomic analysis, offer the potential for unprecedented insights
into the
mechanisms underlying the acquisition of immunity.
She leads a research group that follows two distinct but complementary approaches: basic science focusing on
cellular mechanisms of neurodegeneration, and a programme to translate those findings
into treatments and cures.
Some of their goals include the unravelling of disease
mechanisms by using nanomaterials to track
cellular components and probe the chemical niche of the cells, the transformation of adult human cells
into induced pluripotent stem cells and the delivery of drugs directly to immune and cancer cells.
The application of subclonal reconstruction methods is providing key insights
into tumor evolution, identifying subclonal driver mutations, patterns of parallel evolution and differences in mutational signatures between
cellular populations, and characterizing the
mechanisms of therapy resistance, spread, and metastasis.
Moreover, the data can serve as a basis for studies concerning the evolution of signaling
mechanisms, as well as can give specific insights
into the regulation of basic
cellular processes such as polar cell growth, cell expansion, plant morphogenesis and the plants responses to fungal pathogens.
In conclusion, our study highlights the importance of studying gene — gene interactions in complex diseases and provides insights
into the underlying
cellular and molecular
mechanisms.
Throw small bits of natural dairy
into the mix and you've got a pretty potent trilogy for not just increasing IGF - 1, but also all the fat loss, lean muscle gain, and
cellular repair
mechanisms that accompany a surge in growth hormone.
Because the pathophysiology of cancer is linked to alteration of
cellular gene expression, the bioinformatics toolbox promises to offer countless molecular insights
into mechanisms, diagnostics, and new medical interventions for cancer.