Sentences with phrase «into chimeric»

The pluripotent properties of ES cells can be demonstrated by in vitro differentiation or by reintroduction of these cells back into chimeric embryos by blastocyst injection or morula aggregation.

To do so, the engineered ESCs would be injected into developing mouse embryos, the embryos allowed to develop into chimeric mice (with a fraction of the cells in the adult mice derived from the engineered ESCs), and chimeric adults mated to produce completely transgenic offspring.

Linked RNA - DNA pairs are selectively fished out, then converted into chimeric sequences that can all be read at once using high - throughput sequencing.

No. 4: CAR - T takes a backseat Research into chimeric antigen receptor T - cell (CAR - T) therapy has captured the attention of investors over the past two years, but safety risks could emerge as trial sizes increase, and that could help shift attention to other promising anti-cancer approaches, including NantKwest's (NASDAQ: NK) natural killer cell approach and soon - to - IPO Editas» CRISPR / Cas approach.

Not exact matches

Those two companies, along with their larger competitor Novartis (nvs), are developing experimental chimeric antigen receptor T - cell (CAR - T) technology platforms, which are highly personalized treatments that involve extracting patients» immune cells, re-engineering them to target their specific cancers, and then pumping these sniper - cells back into the body.

Bellicum is among the flurry of biotechs investing heavily into cell therapies such as experimental chimeric antigen receptor T - cell (CAR - T) treatments for cancer (this is the next - gen treatment that involves reprogramming immune cells to become cancer killers and has shown promise in blood cancers, which Bellicum specializes in).

When researchers create «chimeric» mice by injecting iPS cells into early - stage mouse embryos, the resulting animals are unusually prone to cancer.

«This chimeric role of employment / education affords us several concessions, including deferring student loans, increased time off... plus sick and holiday leave, decent benefits, the ability to pay into the UC retirement plan, and the flexibility of participating in lectures, seminar, conferences, and classes.»

After giving the cells a week to get used to each other, the scientists implanted the chimeric concoction into the protective tissue surrounding the kidneys of living mice.

In a 2009 study, University of Georgia at Athens cloning expert Steve Stice created 29 chimeric piglets by injecting pluripotent stem cells into pig embryos before implanting them into a surrogate womb.

The finding could fundamentally change how we look at human stem cell tech: If chimeric monkeys require totipotent cells before they can come into being, it stands to reason that human embryonic stem cell therapy might also require totipotent stem cells to render cures.

The world's first chimeric monkeys were created in a laboratory last year, and they offer surprising new insights into embryonic stem cell therapy: One reason for often - poor treatment outcomes may be that we're using embryos that are, strangely, just too old.

Some worry that such human cells, when combined with animal embryos, could develop into brain cells, sperm, or egg cells in the chimeric offspring.

The same technique — injecting pluripotent stem cells into early embryos — failed with other combinations: The scientists couldn't create rat - pig chimeras, and although they produced human - cow chimeric embryos, they did not transfer them into cows to develop into fetuses.

The SHIV - 89.6 3» construct encodes the HIV - 1 portions of the chimeric virus, cloned into the pBluescript II KS (+) vector (Stratagene).

Expression Level of a Chimeric Kinase Governs Entry into Sporulation in Bacillus subtilis.

Research into such therapies as chimeric antigen receptor T cells (CAR - T) cancer therapies and stem - cell regenerative medicines demand the isolation and purification of viable and functional target cells.

mesothelin - specific chimeric antigen receptor (CAR) were capable of ablating large human mesothelioma tumors when infused into mice.

To further verify their incorporation into host organs, we sacrificed two - week old chimeric mice.

The team engineered the immunoadhesin sequences into the AAV vector and injected the constructs into the muscles of nine rhesus macaques, where the muscle cells then started to produce the chimeric antibodies and secrete them into the bloodstream.

HV cell lines constitutively expressing β - Geo from the CAG promoter (HV lacZ) were fractionated into V+S + and V − S + and their ability to contribute to chimeric embryos assayed by morula aggregation.