These inflammatory macrophages release a variety of proteins, including some that loosen the structure of the cells, allowing acinar cells to
morph into different types of cells.
«Our group pioneered the development of cell culture technology for harvesting large numbers of stem cells from human bone marrow and human umbilical cord blood,» Dr. Yeh said, noting that stem cells from these two sources are abundant and can be
guided into different types of cells using tissue engineering.
«Disturbances to these processes may cause neuronal stem cells to
develop into different types of cells or may cause neurons to migrate to different locations in the brain, changing neuronal circuitry and potentially leading to behavioral disorders like schizophrenia.»
Then, the cells begin to «specialise»
into different types of cell and space out asymmetrically, forming an axis which begins to provide a structure for the embryo to develop along.
«Much of the focus in stem cell research has been how to turn
them into different types of cells such as neurons, but maybe that is not always necessary,» Yamasaki said.