Sentences with phrase «into endoderm»

We have previously reported that our 26 - d protocol closely recapitulates key stages of biliary development, starting with the differentiation of hPSCs into endoderm and subsequently into foregut progenitor (FP) cells, followed by the generation of hepatoblasts (HBs), cholangiocyte progenitors (CPs) expressing early biliary markers and mature CLCs displaying cholangiocyte functionality.

On the other hand, ES cells and cells differentiating into endoderm and mesoderm lineages from ES cells express OCT - 4 in mice and humans [66], and SSEA1 expression is found in other type of cells including neural stem cells and mesenchymal stem cells [67], [68].

Then, by treating the fibroblasts with a unique «cocktail» of molecules and reprogramming factors, they transformed the cells into endoderm - like cells.

On the other hand, cells of line 4.1 differentiated into endoderm lineages more easily than cells of line 11.1 (data not shown).

Not exact matches

The scientists then progressed these endoderm cells two more steps, first into pancreatic precursor cells, and then into fully - functional pancreatic beta cells.

Endoderm cells are cells that eventually mature into many of the body's major organs — including the liver.

ES cells are pluripotent, that is, they are able to differentiate into all derivatives of the three primary germ layers: ectoderm, endoderm, and mesoderm.

Initial imaging analysis of fluorescently labelled human iPSC - derived hepatic endoderm cells, umbilical cord - derived endothelial cells (HUVECs), and mesenchymal stem cells (MSCs) co-cultured in a solidified matrix gel to promote 3D growth found that the different cells collectively and automatically «condensed» into a multicellular central unit.

Additionally, ERCs were reported to be able to differentiate into, or become, cells from the three different germ layers (see the previous post on MSCs for more details): mesoderm (muscle, bone, fat, cartilage, and endothelial cells), ectoderm (neurons), and endoderm (liver, pancreas, and lung cells)(Meng et al., 2007; Patel et al., 2008).

Endoderm cells are a type of cell found in the early embryo, and which eventually mature into the body's major organs — including the pancreas, the home of β - cells.

During the process, the cells begin to form three distinct layers: the endoderm, mesoderm and ectoderm, determining which tissues or organs the cells will then develop into.

When the ESCs had no Chd1 at all, the cells could not differentiate into all of the three germ layers (specifically, endoderm was not detected, and a preference was found for neuronal lineages).

Within this elementary biological structure, three types of cells begin to cluster and develop: the embryonic stem cells (which eventually become the body of the embryo), and two extra-embryonic types of cells - the trophoblast stem cells (which develop into the placenta) and the endoderm stem cells (which go on to form the yolk sac).

Albeit still in rudimentary form - since it can't further develop into a healthy fetus because of the absence of endoderm cells - the newly constructed artificial embryo leads scientists closer to understanding how embryogenesis works.

Novocell scientists pioneered a differentiation process that successfully engineers hES cells into definitive and pancreatic endoderm cells necessary for pancreas formation.

Endoderm cells are a type of cell found in the early embryo, and which eventually mature into the body's major organs — including the pancreas, the home of ß - cells.

(A) A low concentration of FBS in combination with a high concentration of recombinant Activin A could induce iPS cells of line 11.1 into a definitive endoderm lineage.

Most strikingly when introduced back into morulae or blastocysts, the V+S + population is not effective at contributing to the epiblast and can contribute to the extra-embryonic visceral and parietal endoderm, while the V − S + population generates high contribution chimeras.

We show that the fraction of cells present within this state is influenced by factors that both promote and suppress primitive endoderm differentiation, but conditions that support ES cell self - renewal prevent their progression into differentiation and support an equilibrium between this state and at least one other that resembles the Nanog positive inner cell mass of the mammalian blastocysts.

Differentiation into extraembryonic endoderm [21] or neural progenitors [33] are frequent early outcomes of spontaneous differentiation when human ES cells are cultured in the presence of a feeder cell layer, and it is interesting to speculate that the cells are being primed for these fates.

It is probable that these cells represent extraembryonic endoderm, and that they arise directly from stem cells primed to differentiation into this lineage.