Sentences with phrase «into endothelial»

Trans fats might affect systemic inflammation through incorporating into endothelial cell membranes (36), activating cell - specific pathways (37), and affecting macrophage membrane phospholipids (38).

The longer cholesterol circulates in your bloodstream, the higher the likelihood that it will dig its way into an endothelial wall and potentially contribute to atherosclerosis or plaque formation.

These cells could be expanded for at least 20 passages (2 ∧ 20 or at least a million-fold expansion) and differentiated into endothelial cells without any significant change in their morphology (Figure S4).

Direct conversion or reprogramming of human postnatal cells into endothelial cells (ECs), bypassing stem or progenitor cell status, is crucial for regenerative medicine, cell therapy, and pathophysiological investigation but has remained largely unexplored.

The team identified the connections between rs9349379 and EDN1 by deleting a region of DNA at the SNP in human pluripotent stem cells and then converting these immature cells into endothelial cells and vascular smooth muscle cells.

They then transformed these iPSCs into endothelial cells, which line heart valves and blood vessels.

The transplanted stem cells had differentiated into endothelial cells — which form the inner lining of a blood vessel, providing a barrier between blood and spinal cord tissue — and attached to capillaries in the spinal cord.

The study examined nanoparticle entry into endothelial cells and macrophages for the in vitro study, and the same type of cells from the lung, heart and bone marrow for the in vivo component.

«It appears that injury itself can induce fibroblasts to change into endothelial cells so the heart heals better.

That is, instead of just 30 percent of fibroblasts naturally switching into endothelial cells, 60 percent made the switch.

Researchers from the UNC School of Medicine have discovered that cells called fibroblasts, which normally give rise to scar tissue after a heart attack, can be turned into endothelial cells, which generate blood vessels to supply oxygen and nutrients to the injured regions of the heart, thus greatly reducing the damage done following heart attack.

The researchers then differentiated the iPS cells into endothelial cells, which line the interior of the heart and blood vessels, before transplantation.

Rather, parasites move directly from the blood into endothelial cells, where they replicate, cause the cell to burst and then infect neighboring brain cells.

«Yet after AA147 treatment, around 70 percent of the culture turned into endothelial cells that were able to form blood vessels.

AA147 directed the stem cells to develop primarily into endothelial cells, which are essential for blood vessel formation.

Not exact matches

The Weill Cornell researchers» process was more direct: Four transcription factors prompted adult mouse endothelial cells, which line the inside of blood vessels, to turn into HSCs.

Using their nuclei to exert force, they insert themselves between — as well as into — the cells (called endothelial cells) in the vessel walls.

«We can generate cerebral organoids with integrated endothelial tissue, this tissue forms tubes, and we can induce these tubes to sprout» into the nutrient broth that the cerebral organoids grow in, said John Aach, a geneticist in Church's lab.

And they incorporated into the gel a protein known as vascular endothelial growth factor (VEGF), which encourages the growth of blood vessels into the transplanted cells.

Luster's team hopes to further investigate the characteristics of joints that underlie the critical role of C5a in initiating type III hypersensitivity and whether specific molecules expressed on endothelial cells lining joints play a role in transporting C5a and chemokines from the joint space into adjacent blood vessels.

These treatments involve regular injection of vascular endothelial growth factor inhibitors (anti-VEGF) into the eye.

In a collaborative effort between the Gladstone laboratories of Benoit Bruneau, PhD, Katherine Pollard, PhD, and Dr. Srivastava, the scientists used stem cell technology to make large amounts of endothelial cells from patients with CAVD, comparing them to healthy cells and mapping their genetic and epigenetic changes as they developed into valve cells.

A team from Cold Spring Harbor Laboratory in Long Island, N.Y., reports that it staved off full - blown metastasis in mice by preventing mini-tumors in the lungs from recruiting stem cells called endothelial progenitors, which assemble into blood vessels to nourish the malignancy.

To explain their findings, the authors suggest that resveratrol's vasodilating effects via endothelial cells might enhance infiltration of inflammatory cells into the central nervous system, which in turn might play a key role in the pathogenesis of MS.

The epithelium's maturation into a villus intestinal epithelium with long finger - like extensions was helped along by co-culturing human intestinal microvascular endothelial cells on the opposite side of the shared matrix - coated porous membrane in the «vascular» channel where they assembled a surrogate blood vessel with a hollow lumen through which feeding medium was flowed.

To verify that the process worked, the endothelial cells with the inversion - corrected genes were transplanted into F8 deficient mice (mice with hemophilia A) and the mice started producing the F8 clotting factor on their own, which essentially cured them of hemophilia A.

A specific lung - targeting molecule is attached to the carrier's surface and the steriod, dexamethasone, an anti-inflammatory, is loaded into the nanogel, which then binds to lung endothelial cells lining the inside wall of the blood vessels where it rapidly delivers the drug.

He then injected human endothelial cells into the collagen structures of blood vessels to recolonise the surfaces of blood vessels.

These endothelial - derived factors stimulate the recruitment of tumor - promoting macrophages into the tumor.

The newly developed porous films do not require an addition of costly growth factors, and they are capable of adsorbing vascular endothelial growth factors (VEGFs) that occur naturally in the body and taking them into the film materials.

Key elements of the immune system, they also have the ability to turn into several cell types after having passed the endothelial barrier, in order to fulfil different functions depending on the tissue.

During the creation of new blood vessels, the vascular endothelial growth factor (VEGF) protein differentiates stem cells into vascular endothelial cells and stimulates them to create new blood vessels.

In addition, when these transcription factors lose their function, terminal differentiation into the vascular endothelium (completion of differentiation) is completely suppressed, and genes that are key to differentiation into vascular endothelial cells as well as transcription factors that maintain the undifferentiated state are adversely induced.

The endothelial cells have a receptor for transferrin that acts like a gatekeeper: When transferrin binds to a receptor on the blood side of the barrier, the endothelial cell transports it (and its iron cargo) to the other side and spits it out into the brain.

Genentech scientists led by Mark Dennis designed an antibody with two arms — one that binds to BACE1 and inhibits its activity and one that binds to the transferrin receptor and tricks endothelial cells into transporting the antibody across the blood - brain barrier.

At that key point, Takebe added two more types of cell known to help to recreate organ - like function in animals: endothelial cells, which line blood vessels, taken from an umbilical cord; and mesenchymal cells, which can differentiate into bone, cartilage or fat, taken from bone marrow.

Each of the endothelial cell lines demonstrated an ability to orient into capillary - like structures when placed onto a Matrigel surface (Fig. 5A) ⇓.

Results: After dividing corneas into central, intermediate, and peripheral sections, the dissected endothelial tissues exhibited positive telomerase activity in the peripheral and intermediate sections.

Endothelial progenitor cells (EPCs) differentiate into the cells that make up the lining of blood vessels, and so play roles in vasculogenesis and angiogenesis.

We will combine methods from the fields of immunology, developmental biology and angiogenesis to understand in vivo the development and lineage - specific function (s) of resident macrophages, thereby opening new venues of research into the interaction between macrophages and endothelial cells in response to tissue damage.

Initial imaging analysis of fluorescently labelled human iPSC - derived hepatic endoderm cells, umbilical cord - derived endothelial cells (HUVECs), and mesenchymal stem cells (MSCs) co-cultured in a solidified matrix gel to promote 3D growth found that the different cells collectively and automatically «condensed» into a multicellular central unit.

Additionally, ERCs were reported to be able to differentiate into, or become, cells from the three different germ layers (see the previous post on MSCs for more details): mesoderm (muscle, bone, fat, cartilage, and endothelial cells), ectoderm (neurons), and endoderm (liver, pancreas, and lung cells)(Meng et al., 2007; Patel et al., 2008).

Release of intracellular calcium stores facilitates coxsackievirus entry into polarized endothelial cells.

HIF - 2α expression regulates sprout formation into 3D fibrin matrices in prolonged hypoxia in human microvascular endothelial cells.

ieCPCs can also develop into each of the three different types of heart cells: cardiomyocytes, endothelial cells, and smooth muscle cells.

Identifying the factor released by endothelial cells could lead, said Stainier, to a mechanism for prompting naive, or undifferentiated, cells to develop into red blood cells, which could then be used to boost the blood supply.

Studies on interactions among tumor cells, fibroblasts and endothelial cells are also done in 3 - D models, in which cells are embedded into collagen to mimic the tumor microenvironment.

As specific examples, our studies seek to define the molecular basis for platelet and endothelial cell responses and then extend these into patients to determine whether newly identified mechanisms can be targets for diagnosis, prevention and treatment of cardiovascular diseases.

In those studies, sorted progenitor cells, some of which could become endothelial cells, were introduced into the heart.

Furthermore, ASCs secreted high levels of vascular endothelial growth factor (VEGF) into the wound site, thereby promoting accelerated angiogenesis and encouraging higher levels of wound healing.