Not exact matches
Four weeks
into your pregnancy, your baby (now an embryo) consists of two layers of cells — the
epiblast and the hypoblast.
It will consist of two layers of cells, the
epiblast and the hypoblast, that will later on develop
into the essential organs and body parts that your baby requires to function on their own.
Hayashi then drew on other research showing that one key regulatory molecule (activin A) and a growth factor (basic fibroblast growth factor) could convert cultured early embryonic stem cells
into cells akin to
epiblasts.
Most strikingly when introduced back
into morulae or blastocysts, the V+S + population is not effective at contributing to the
epiblast and can contribute to the extra-embryonic visceral and parietal endoderm, while the V − S + population generates high contribution chimeras.
However, when these fractions are placed
into differentiation either in vivo or in vitro, the V+S + population tends to colonize the PrEn lineages, while V − S + cells tend towards
epiblast.
Similar observations have been made with respect to expression of stella in mouse ES cells, with stella positive cells, which resemble the inner cell mass, reversibly converting
into stella negative cells which are more akin to
epiblast [11].