Sentences with phrase «into epithelial»

The mechanism by which they do this is pretty darn cool: gram - negative bacteria secrete acyl - homoserine lactones — compounds that are similar in taste to bitter plants like angelica or dandelion, thereby activating T2R cells and triggering a release of antibacterial compounds into epithelial cells.

We developed a way of getting siRNAs into epithelial cells by either mixing them with a transfection lipid used to introduce exogenous nucleic acids into cells in the lab or by adding a cholesterol tag to the end of the RNA sequence that allowed the RNA to be taken up into cells.

Uptake of rabies virus into epithelial cells by clathrin - mediated endocytosis depends upon actin.

They then converted the iPS cells into epithelial stem cells, normally found at the bulge of hair follicles.

Xiaowei «George» Xu, MD, PhD, associate professor of Pathology and Laboratory Medicine and Dermatology at the Perelman School of Medicine, University of Pennsylvania, and colleagues published in Nature Communications a method for converting adult cells into epithelial stem cells (EpSCs), the first time anyone has achieved this in either humans or mice.

Not exact matches

Stem cells have also been identified in human milk, and have the potential to differentiate into mammary epithelial lineages under mammary differentiation conditions in vitro, as well as other cell types in corresponding microenvironments, including bone cells, brain cells, liver cells, pancreatic beta cells and heart cells.

In the first half of pregnancy secretory differentiation (the differentiation of alveolar epithelial cells into milk - secreting cells), ductal branching and lobular formation of the breast (mammogenesis) occur.

As lipid droplets exit the mammary epithelial cell, they are enveloped by cell membrane and secreted into milk as membrane - bound globules of fat.

Stage I lactogenesis, or secretory initiation, occurs during pregnancy and is defined by the differentiation of mammary alveolar epithelial cells into specialized secretory cells, termed lactocytes (1).

Ten years ago, the team at Advanced Cell Technology announced that it had successfully converted human embryonic stem cells into retinal pigment epithelial cells.

Bdellovibrio bacteriovorus inhibits Staphylococcus aureus biofilm formation and invasion into human epithelial cells.

The now - mesenchymal cells can then travel to a remote site, where they eventually convert back to their epithelial state and clump together into a secondary tumor.

«With Rudolph,» Farber says, «the coral DNA got inserted into a gene that is normally expressed in the nasal epithelial cells, the cells of his nose.

A membrane — designed to support the cultivation and differentiation of human nasal epithelial stem cells — was inserted into a small chamber on the device and fresh or contaminated air was fed through a tiny channel.

The mechanisms that promote or enable drug resistance include drug inactivation, drug target alteration, drug removal from cells, DNA damage repair, cell death inhibition and the epithelial - mesenchymal transition (EMT) that enable solid tumors to transform into more metastatic grades.

In this pilot study to test the safety of putting iPS - derived cells into humans, the six are all receiving a graft of new retinal pigment epithelial cells, which serve to maintain the eye's light - sensing cells.

What's more, the researchers discovered two years ago that the suppression of Esrp activity helps to enable a process called the epithelial - mesenchymal transition (EMT), in which epithelial cells acquire properties allowing them to detach and develop into new tissue.

She and her group had studied the nature and function of epithelial cells, the gut - lining cells that come into contact with breast milk in nursing infants.

We injected the chemical into rats and demonstrated that it makes the epithelial lining of the uterus proliferate — a sign of its being an estrogen.»

They found that infection of the narrowest airways of the lung by PIV3 alone caused moderate levels of inflammation, but after infection by PIV3 expressing RSV NS2, the epithelial cells lining the narrow airways were shed rapidly into the airway lumen.

«But what we've now shown is that RSV has an increased ability to cause airway obstruction because, during an RSV infection, the virus expresses a specific RSV - encoded non-structural protein, or NS2, in epithelial cells, causing the cells to shed from the airway lining and into the airway lumen.

When they delivered this virus into the noses of mice and ferrets, the animals» epithelial cells produced the desired antibodies; they then «challenged» the animals with a range of dangerous influenza viruses that no single vaccine can outwit, including H5N1, which kills both birds and humans, and the H1N1 that caused the infamous 1918 pandemic.

But the pH - responsiveness also allows the bacterium to escape a certain death by detaching from epithelial - and mucus cells that are shed into the gastric juice,» says Jeanna Bugaytsova, researcher at Department of Medical Biochemistry and Biophysics and first - author of the article.

The EMT is a biological process wherein epithelial cells (cells that line the cavities and surfaces of blood vessels and organs) become mesenchymal (skeletal) stem cells that can move throughout the body and differentiate into a variety of cell types.

The resulting organoids could either be banked for future use or immediately fragmented and seeded into the «epithelial» channels of multiple Organ Chips where they were further matured by flowing specialized culture medium and applying mechanical stimulation to the channels to mimic physiological peristalsis - like motions.

To test their idea for the dry form, Amir Kashani of the University of Southern California in Los Angeles and his colleagues coated 6 by 4 - millimetre slithers of polymer with retinal pigment epithelial cells they had grown, then transplanted these into four people.

She said: «This is the first large - scale study looking into whether habitual intake of different flavonoids can reduce the risk of epithelial ovarian cancer.

According to Dr. Bleich and his co-investigators, «Epithelial barrier function is predominantly dependent on tight junction proteins, which regulate transport into and between cells.

He and his colleagues will inject into patients» eyes retinal pigment epithelial cells that ACT derived from hES cells.

«An immediate use of our study will be to look into other human epithelial tissues to see if this finding is unique to the breast or a more general phenomenon,» says Dr. Gilley.

The research team then tested RMC - 1 in cultured human airway epithelial cells and mouse models of asthma (via injection into the animals» peritoneal cavities).

Starting with procedures other research teams had previously worked out to convert iPSCs into keratinocytes, Xu's team demonstrated that by carefully controlling the timing of the growth factors the cells received, they could force the iPSCs to generate large numbers of epithelial stem cells.

The epithelial stem cells, when implanted into immunocompromised mice, regenerated the different cell types of human skin and hair follicles, and even produced structurally recognizable hair shaft, raising the possibility that they may eventually enable hair regeneration in people.

«We have genetically different mice, but we implanted the same epithelial cells into all of them,» says Mao.

When normal cells are transformed into cancer cells, this epithelial tissue can take on the characteristics of embryonic tissue, known as mesenchymal tissue, which is comprised of unspecialized cells that will develop, as the embryo matures, into more specialized tissues.

MimEX ™ Tissue Models System provides a platform for the isolation, expansion, and differentiation of adult epithelial stem cells into 3 - D ex vivo organ tissue.

Subsequent studies, as reviewed by Daniels et al. [11] and Lavker and Sun [12] showed that some cells located in the anterior limbus are stem cells which partially differentiate into transient amplifying cells while migrating centrally into the posterior epithelial layer of the cornea.

More important, by introducing miR - 200, they managed to activate production of E-cadherin protein and reverse tumors from a more - invasive mesenchymal into a less - invasive epithelial form.

Using Cultrex ® BME, MimEX ™ Tissue Models System provides a platform for the isolation, expansion, and differentiation of adult epithelial stem cells into 3 - D ex vivo organ tissue.

Preliminary data we have now obtained further indicate that in somite cells, the activation of the NOTCH pathway triggers a «signalling module» that couples the initiation of myogenesis with the epithelial - mesenchymal transition (EMT) that allows them to migrate into the growing muscle.

The stem cells in the bulge are multipotent epithelial stem cells, and can become, or differentiate into, all the epithelial cell types in the follicle (including hair follicles, epidermis, and sebaceous glands)(Oshima et al., 2001).

We have recently shown that in avian embryos, muscle formation is initiated by Delta1 - positive neural crest cells migrating from the dorsal neural tube that, in passing, trigger NOTCH signalling and myogenesis in selected epithelial somite progenitor cells, allowing them to migrate into the nascent muscle to differentiate.

Assembly of connexin43 into gap junctions is regulated differentially by E-cadherin and N - cadherin in rat liver epithelial cells.

It also provides new insights into how the epithelial cells that line the body and its organs stick together.

In this pilot case, a sheet of retinal pigment epithelial cells was transplanted into a patient.

A trial being conducted by Advanced Cell Technology is testing the effectiveness of MA09 - hRPE, human ESCs terminally differentiated into retinal pigment epithelial (RPE) cells, in treating degenerative macular diseases.

In chick embryos, skeletal muscle formation is initiated by migrating Delta1 - expressing neural crest cells that trigger NOTCH signaling and myogenesis in selected epithelial somite progenitor cells, which rapidly translocate into the nascent muscle to differentiate.

Scientists study dorsal closure, which occurs during the development of the fruit fly Drosophila melanogaster, to gain insights into wound healing in humans, as both processes involve closing a gap in the skin by stretching the surrounding epithelial cells over it.

We have also recently shown that carcinogenic strains of H. pylori can selectively activate B - catenin, and this is due to translocation of CagA into the host epithelial cell.

The company has turned human embryonic stem cells into retinal pigment epithelial cells, which will be surgically implanted into the eye.