They then converted the iPS cells
into epithelial stem cells, normally found at the bulge of hair follicles.
Xiaowei «George» Xu, MD, PhD, associate professor of Pathology and Laboratory Medicine and Dermatology at the Perelman School of Medicine, University of Pennsylvania, and colleagues published in Nature Communications a method for converting adult cells
into epithelial stem cells (EpSCs), the first time anyone has achieved this in either humans or mice.
Not exact matches
Stem cells have also been identified in human milk, and have the potential to differentiate
into mammary
epithelial lineages under mammary differentiation conditions in vitro, as well as other
cell types in corresponding microenvironments, including bone
cells, brain
cells, liver
cells, pancreatic beta
cells and heart
cells.
Ten years ago, the team at Advanced
Cell Technology announced that it had successfully converted human embryonic
stem cells into retinal pigment
epithelial cells.
A membrane — designed to support the cultivation and differentiation of human nasal
epithelial stem cells — was inserted
into a small chamber on the device and fresh or contaminated air was fed through a tiny channel.
The EMT is a biological process wherein
epithelial cells (
cells that line the cavities and surfaces of blood vessels and organs) become mesenchymal (skeletal)
stem cells that can move throughout the body and differentiate
into a variety of
cell types.
Starting with procedures other research teams had previously worked out to convert iPSCs
into keratinocytes, Xu's team demonstrated that by carefully controlling the timing of the growth factors the
cells received, they could force the iPSCs to generate large numbers of
epithelial stem cells.
The
epithelial stem cells, when implanted
into immunocompromised mice, regenerated the different
cell types of human skin and hair follicles, and even produced structurally recognizable hair shaft, raising the possibility that they may eventually enable hair regeneration in people.
MimEX ™ Tissue Models System provides a platform for the isolation, expansion, and differentiation of adult
epithelial stem cells into 3 - D ex vivo organ tissue.
Subsequent studies, as reviewed by Daniels et al. [11] and Lavker and Sun [12] showed that some
cells located in the anterior limbus are
stem cells which partially differentiate
into transient amplifying
cells while migrating centrally
into the posterior
epithelial layer of the cornea.
Using Cultrex ® BME, MimEX ™ Tissue Models System provides a platform for the isolation, expansion, and differentiation of adult
epithelial stem cells into 3 - D ex vivo organ tissue.
The
stem cells in the bulge are multipotent
epithelial stem cells, and can become, or differentiate
into, all the
epithelial cell types in the follicle (including hair follicles, epidermis, and sebaceous glands)(Oshima et al., 2001).
The company has turned human embryonic
stem cells into retinal pigment
epithelial cells, which will be surgically implanted
into the eye.