This product was recently evaluated as a topical treatment for generalized demodicosis in a small study involving 16 dogs older than 1 year of age.16 Dogs were divided
into two
equal groups and treated with the spot - on at the proposed minimum
dose rate (20 mg / kg of both metaflumizone and amitraz, 0.133 ml / kg) on days 0, 28, and 56 or days 0, 14, 28, 42, 56, and 70.
The total daily
dose of artificial milk should be progressively increased over a period of 4 weeks from about 15 mL to about 20 mL per 100 g of body weight, and should be divided
into 5 - 6
equal portions given at regular intervals through the day.
The total daily
dose should be divided
into 2 portions that are not necessarily
equal, and the portions should be administered approximately 12 hours apart (i.e., morning and evening).