Not exact matches
So if you look at testosterone andro it can also float downstream
into either estrone, or estradiol estrone, and estradiol.And then from there it can get converted in the liver to
estriol.
Excessive aromatization, in addition to its «feminizing» effects, may increase prostate cancer risk since estradiol can be metabolized to estrone, which can then be converted to either protective 2 - hydroxyestrone (2 - OH) or
Estriol (E3) OR
into potentially pro-carcinogenic 16α - OH estrone.
This may not be advisable since estrone may be metabolized to either protective 2 - hydroxyestrone (2 - OH), 2 - methoxyestrone (2 - CH3O) or
Estriol (E3) OR
into pro-carcinogenic 4 - hydroxyestrone (4 - OH estrone) and 16α - OH estrone.
Glucose and inositol are oxidized in the liver to glucuronic acid and then bound
into uridine diphosphate glucuronate (UDG), which is used by the enzyme uridine diphosphate transglucuronylase to convert 2 - OH estrone, 4 - OH estrone, 16α - OH estrone, estradiol or
estriol into water - soluble glucuronides, which can be excreted through the urine as well as bile.
To be able to safely and effectively prescribe hormone replacement therapy (BHRT or HRT) will necessitate knowing not only how much estrone, estradiol and
estriol are in circulation, but how much is active (free plus conjugated [potentially active]-RRB-, and
into what forms each estrogen is being metabolized: Is she predominantly producing protective or carcinogenic estrogen metabolites?
Here's the rub: Pregnancy puts your endocrine glands
into overdrive in order to make the sky - high levels of
estriol and progesterone that your baby requires.
During the pregnancy many autoimmune diseases including Hashimoto's thyroiditis go
into remission due to the production of high levels of progesterone and
estriol.