Sentences with phrase «into gene function»

Loss - of - function mutations can disrupt both copies of a given gene in humans and phenotypic analysis of such «human knockouts» can provide insight into gene function.

Critical to ethical review is a cost / benefit analysis; the welfare cost to the animals must be balanced by the benefit of knowledge gained into gene function and the role of genes in human health and disease.

Given how useful any insights into gene function are for understanding the genetic basis of disease, the data are «priceless,» says Kári Stephánsson, a geneticist at deCODE in Reykjavík.

The bad news is that much of this information is still mysterious because we don't know the complete genomes of most of the microbes in there, but the good news is that you can get an insight into the gene functions, not just which microbes are there.

Not exact matches

The researches found that the transgene was inserted into an active region of the genome, thereby disrupting the coding sequence and ultimately the function of the plants own OsAux1 gene.

Blasting GM DNA into a plant arbitrarily and out of a sequence of genes that has evolved over hundreds of millions of years, in a manner aimed to optimise the functioning of an organism, is risky and unpredictable, and bound to destabilise the biochemistry of the plant.

«Decoding the genome's cryptic language: New tool to map RNA - DNA interactions could help researchers translate gene sequences into functions.»

In this special section of Science, expert contributors retrace the long and tortuous path leading to the mapping and identification of the BRCA1 gene; discuss the ways in which BRCA mutation status has been integrated into the clinical management of patients in high - risk families; and highlight the role of the BRCA proteins in preserving the structural and numerical integrity of chromosomes throughout the cell cycle, a function that may explain their tumor suppressor activity.

The neomycin strategy allows researchers to make sure that the gene is functioning properly before it's inserted into a cow, he says.

«Y chromosomes are vital for male development and fertility and it will be fascinating to gain a better insight into the function that these newly discovered genes have in different species,» she says.

Representatives from both the scientific and legal communities expressed outrage that patent rights to genes could be awarded on the basis of work that provided no insight into how the gene might function.

When Blakely's team spliced the DNA sequence that encodes the relevant fly amino acid into the mouse serotonin transporter gene, the mice now made a transporter that was 80 times less sensitive to cocaine, while allowing the transporter to function completely normally.

«This could mean that the reversal or suppression of pathological gene expression by beta blockers is somehow protective against heart failure, but it's something we would need to look into further to understand how individual genes function in the heart.»

For his part, Collins, who has led NIH since 2009 and been kept on by the Trump administration, pointed to an array of promising NIH activities, including the development of new technologies to provide insights into human brain circuitry and function through the Brain Research through Advancing Innovative Neuroethologies (BRAIN initiative) and the use of the gene - editing tool CRISPR - Cas9 to correct mutations and clear the way to develop and test a «curative therapy» for the first molecular disease: sickle cell disease.

At first, the extra letters were slipped into the bacteria far from working genes, to avoid disrupting their function.

The scientists will now look into possible techniques to restore the function of pejvakin, particularly using gene therapy, which has already proved successful in conserving hearing in mice lacking in pejvakin, even when they are overexposed to noise.

First, the researchers looked at published databases of positively selected brain genes, which have been classified into 22 categories according to their function.

«New innovative method for delivering genes into cells: Modification of cell physiological function with novel parallelized electroporation of mammalian cells by using electrostatic manipulation in a water - in - oil droplet.»

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

Others want to deliver working copies of broken genes into retinal cells, restoring their function.

The virus was able to shuttle the correct gene into lung tissue in the laboratory and restore its function.

How do these imprinted genes related to brain function fit into the scheme of intersexual warfare?

The team realized that the Salmonella genes they found resembled genes in other bacteria with a similar function — transporting the nutrient fructose - lysine into E. coli.

As an example, the current study identified and provided insight into the function of several genes, not previously known to be involved in the taste system, related to cell motility.

Mutations generally abrogate gene function, indicating that the maize allele acts by suppressing lateral shoot development, converting grassy teosinte into slim, single - stalked modern corn and male into female reproductive structures (7).

Researchers are investigating ways to insert functioning versions of the clotting factor gene into patients» own cells.

Gene therapy uses a virus to insert a functioning copy of a gene into defective ceGene therapy uses a virus to insert a functioning copy of a gene into defective cegene into defective cells.

The roadmap outlines future research directions toward the goal of enhancing human radioresistance, including upregulation of endogenous repair and radioprotective mechanisms, possible leeways into gene therapy in order to enhance radioresistance via the translation of exogenous and engineered DNA repair and radioprotective mechanisms, the substitution of organic molecules with fortified isoforms, the coordination of regenerative and ablative technologies, and methods of slowing metabolic activity while preserving cognitive function.

With a cell - by - cell assessment of gene activity they are monitoring how precursor cells shape and organize themselves into something loosely resembling a functioning liver.

And that got us into this broad question of: How do new genes» functions evolve?»

Furthermore, besides offering valuable insight into the function of this novel RNA type, the researchers also believe that the findings will open new avenues for novel treatments in which cell - specific enhancer sequences can be targeted to alter gene expression.

Only then do the embryo's own genes fully kick into gear and begin to function.

With further research into how these genes affect the brain, it could become possible to understand how genes linked to schizophrenia affect people's cognitive function,» said McIntosh.

When researchers later added the genes back into the cells experimentally, immune function was restored.

Hence, biologists for decades have studied the proteins that control how genes are transcribed into mRNA and how the mRNA is read and translated into a functioning protein.

After inserting more than 400 human genes into yeast cells one at a time, researchers found that almost 50 % of the genes functioned and enabled the fungi to survive.

When technicians move the nucleus of an adult cell into an egg, the clone will survive only if the egg successfully reprograms the newly installed genes to function as they would in an embryo.

[The intracellular domain's function of] transcribing a gene into a protein that then performs some function within the cell generally takes about two hours, but we were seeing leakage within 30 minutes of blocking Notch1, further suggesting that whatever process controls the permeability of the barrier is operating via a completely different mechanism,» says Bill Polacheck, Ph.D., Postdoctoral Fellow at the Wyss Institute and co-first author of the paper.

Next, the researchers discovered a set of genes and compounds that can transform these cells into functioning liver cells.

Gene loss tends to happen when bacteria settle into a comfortable environment and no longer need certain functions, von Dohlen says, and it is what researchers think happened to organelles.

In addition, when these transcription factors lose their function, terminal differentiation into the vascular endothelium (completion of differentiation) is completely suppressed, and genes that are key to differentiation into vascular endothelial cells as well as transcription factors that maintain the undifferentiated state are adversely induced.

Researchers have developed a set of genetic switches that can be built into engineered organisms, to control the function of genes they need to survive.

Their findings shed new light on the animal's complex biology, including insight into the function of genes linked to immunity and meat quality.

When human genes apparently under selection were categorized using a software program that groups them according to biological function, they clustered into six different categories.

The DNA contains some 1260 genes, 50 of which code for functions never before seen in viruses, including DNA repair and translating mRNA into protein.

An improved understanding of the biological background of musical aptitude can contribute new insights into, for instance, genes that affect normal brain functions, the interactions between genes and the environment and the significance of music as a form of therapy.

They took short pieces of RNA which are able to turn off the function of specific genes, attached them to highly concentrated viruses, and then, using ultrasound to guide the needle without damaging surrounding tissue, they injected the viruses into the sacs of mouse embryos.

Gene therapy offers the possibility of replacing the function of the defective or missing gene with that of a therapeutic gene inserted into the cGene therapy offers the possibility of replacing the function of the defective or missing gene with that of a therapeutic gene inserted into the cgene with that of a therapeutic gene inserted into the cgene inserted into the cell.

Since then he has continued to investigate new strategies to overcome the major hurdles to safe and effective gene transfer, translate then into new therapeutic strategies for genetic disease and cancer, and allowed new insights into hematopoietic stem cell function, induction of immunological tolerance and tumor angiogenesis.

«This data allows classification of all human protein - coding genes into those coding for house - hold functions (present in all cells) and those that are tissue - specific genes with highly specialized expression in particular organs and tissues, such as kidney, liver, brain, heart, pancreas.