Sentences with phrase «into gene models»

Not exact matches

The research opens the possibility of a new model organism for human heart health and the distant prospect of incorporating such a gene into humans.

With the advent of new gene editing techniques, some less common animal models such as octopuses may find their way into scientists» toolkits.

Finally, the authors addressed two major challenges for any study that generates large data - sets of individual genes and proteins in model organisms like yeast: How to assemble the data into coherent maps?

Two years into her research on a mouse - model study of a gene pathway's role in the immune system, she joined UCB Celltech.

«New gene editing technique turns human pluripotent stem cells into a model system for polycystic kidney disease.»

The CRISPR - Cas9 technology allows researchers to transiently introduce DNA double - strand breaks into the genome of cells or model organisms at genes of choice.

By studying how these genes cause defects in fly and mouse models, we can improve our insights into the mechanisms related to human disease,» said corresponding author and Dr. Hugo J. Bellen, professor of neuroscience and molecular and human genetics at Baylor College of Medicine and an investigator at the Howard Hughes Medical Institute.

They directly injected into the cerebrospinal fluid of a mouse model of Alzheimer's — adult animals in which plaques were well established — viral vectors carrying genes for one of the three APOE variants or a control protein.

But people often reject ideas which don't fit into the bacterial model of gene regulation, which is that genes are turned on and off by proteins binding to DNA.

«We combined clustering and classification into the developed framework to help in detecting the links between the various genes within the model and to validate the outcome, respectively.»

Easily accessible from nasal biopsies, these cells — which belong to nerve tissues and can differentiate into neurons — constitute an interesting model to identify the genes and proteins whose expression is deregulated in patients with ASD.

However, in developing brain cells, the researchers found TLR3 activation also influences 41 genes that add up to a double whammy in this model — diminished stem cell differentiation into brain cells and increased cell suicide, a carefully controlled process known as apoptosis.

It's now possible to not only model disease using the cells, but also to compare iPSCs from humans to those of our closest living relatives --- great apes, with which we share a majority of genes --- for insight into what molecular and cellular features make us human.

Given his training in developmental biology, Raman focused the team to seek a novel drug target on genes important to the development of model organisms — fruit flies (Drosophila) and yeast (Saccharomyces cerevisiae)-- rather than on oncogenes that transform a normal cell into a cancer cell.

The scientists also delivered components of the CRISPR system directly into the colon wall to quickly model colon cancer by editing the APC gene.

Otoferlin's size has precluded rescue experiments in which a modified mRNA for otoferlin is transfected into an animal model to replace a suppressed or knocked - down otoferlin gene causing deafness.

Led by Youngchul Sung, the team engineered a strand of DNA containing two genes from TB and injected it into mice that model chronically sick patients.

For example, we know that certain genes are responsible for autism and can use our model to give us insight into at what point the disorder begins developing.»

Conversely, fundamental research using mouse models can identify genes associated with disease and provide insights into pathogenic mechanisms underlying environment - driven diseases, including infectious diseases and cancer.

Current projects are investigating: 1) the expression of inflammatory genes during ischemia and reperfusion of kidneys during urology transplantation and in mouse models; 2) the expression of inflammatory genes and proteins in urine as markers indicating the presence of rejection in renal allografts; and 3) the role of adhesion molecules and chemokines in directing leukocyte infiltration into organ allografts.

Dr. Coyle's Laboratory for Psychiatric and Molecular Neuroscience takes advantage of insights into recently identified genes that confer risk for schizophrenia and related disorders and translates them into genetic mouse models to determine how these mutations affect brain changes as well as function, neurochemistry, and behavior.

Matz and his colleagues developed a model to estimate the ability of the common coral species Acropora millepora to evolve by redistributing existing heat - tolerance genes, taking into account the coral's present - day genetic diversity and how far its larvae migrate before settling down.

This knowledge, which will only be rapidly obtainable in the model organisms, will allow the reduction of most of the approximately 70,000 individual genes encoded by the human genome into a much smaller number of multicomponent, core processes of known biochemical function.

Appropriate animal models and translational research to study sex differences are needed to get more insight into the pathophysiology and complex interplay of hormones, genes, lifestyle, and environment.

To create the model, called RapidCaP, scientists surgically deliver gene mutations directly into the prostate.

His lab has extensive experience evaluating and modulating T cell responses to tumors and viruses, including introducing genes into T cells to impart specificity and modulate function, designing strategies to overcome tolerance and enhance in vivo activity, and developing mouse models that more accurately model human immune responses to candidate vaccines.

The researchers hoped to create a cellular model to parse the effects of specific gene mutations, according to a press release, but in the process they discovered that skin cells from FOP patients were much more readily converted into iPSCs than cells from healthy individuals.

Extending these results into rodent models of H. pylori - induced inflammation and carcinogenesis (Mongolian gerbils and mice), we have shown that inactivation of such genes attenuates the development gastric injury and cancer.

Integrating this new information into computational models, my colleagues and I predicted that about 5 percent of HARs function as noncoding RNAs, while most are enhancers that control gene expression during embryonic development.9

In this study, the team delved deep into the nucleus of cells belonging to mouse and zebrafish embryos — two important animal models of embryonic development — in order to determine how the Dll4 gene is turned on.

Reporting in Nature Medicine this week, Philip Johnson, a professor of pediatrics at the University of Pennsylvania, in Philadelphia, and his colleagues managed to protect monkeys from infection with the simian immunodeficiency virus (SIV), the animal model that is closest to HIV, by shuttling a gene into their muscles that produces antibody - like molecules that work against SIV.

Researchers removed the gene for GFP from jellyfish, cloned it, and introduced it into the cells of the bacterium E. coli and in C. elegans, a soil nematode widely used as a biological model.

«It's hard to fit every single locus in the genome into one specific model of gene regulation.

This brings a real and immediate need for model organism research platforms to put disease - causing genes into a biological context.

The researchers then transplant these progenitor cells into the hippocampi of mice that carry the apoE4 gene and model aspects of Alzheimer's disease.

Researchers have managed to insert that gene into mice to make a living, breathing model of a human disease that mice would otherwise never acquire.

It can efficiently introduce DNA into a cell to be incorporated into its genetic make - up, i.e. induce high gene expression level, especially in both human and mouse breast cancer cell lines, and mouse breast cancer model.

Using the fruit fly Drosophila, a standard lab model for studying animal biology, the researchers discovered a cascade of molecular signals that program gene activity to drive the fly from one stage of maturation to the next, like a baby turning into an adult.

Insight into the processes to which these genes contribute is exploding as researchers assess the effects of the alterations, and pharmaceutical companies are using the resulting mouse models of disease to develop drugs.

With AMG genes that flow into the GTs and «63» models as well, the Mercedes - AMG C 43 Coupé brings the racetrack sensation at drivers» fingertips.