Shah and his team loaded the herpes virus into human MSCs and injected the cells
into glioblastoma tumors developed in mice.
Not exact matches
In 2009 he had been diagnosed with a type of rapidly growing brain
tumor called a high - grade astrocytoma that, despite aggressive treatment, eventually evolved
into a
glioblastoma — the highly malignant brain
tumor that also took the lives of Vice President Joe Biden's son, Beau, in 2015 and former Sen. Ted Kennedy in 2009.
Testing each of these factors for their ability to return differentiated
tumor cells to a stem - like state, identified a combination of four — POU3F2, SOX2, SALL2 and OLIG2 — that was able to reprogram differentiated
tumor cells back
into glioblastoma stem cells, both in vitro and in an animal model.
From tissue and cell samples from five
glioblastoma patients, the scientists obtained 33 individual cancer cells capable of reproduction, which grew
into very different
tumors in the lab.
Another is that the transplanted bits of
tumor act nothing like cancers in actual human brains, Fine and colleagues reported in 2006: Real - life
glioblastomas grow and spread and resist treatment because they contain what are called
tumor stem cells, but
tumor stem cells don't grow well in the lab, so they don't get transplanted
into those mouse brains.
The
tumors studied fell
into the broad category of high - grade gliomas: diffuse intrinsic pontine glioma, which strikes school - aged children; pediatric cortical
glioblastoma, which affects primarily teens and young adults; anaplastic oligodendroglioma, which affects young adults; and
glioblastoma multiforme, which affects older adults.
«When we compared the gene signature activity of
glioblastoma cells from around 60 patients we found that a large number of patients could be divided
into subgroups that showed a correlation between gene activity,
tumor cell characteristics and cell of origin similar to the one we had seen in the mouse study.