Sentences with phrase «into hair cells»

The researchers then tracked which supporting cells turned into hair cells by tagging them with a fluorescent chemical and watching the tissues for at least 4 days.

The work contradicts previous studies that found that multiple types of unidentified supporting cells transform into hair cells when Notch signaling is blocked.

«Knowing about these Lgr5 cells is valuable for us because it gives us a target cell population to study as we try to figure out how to better manipulate them and turn them into hair cells in an adult,» Edge says.

Not exact matches

The inner ear is lined with approximately 30,000 sensitive hair cells that convert sound energy into electrical signals that travel to the brain.

Researchers deliver small interfering RNAs loaded into nanoparticles into the ears of adult guinea pigs to regenerate hair cells damaged by noise.

Another gene, PCDH15, plays a role in the hair cells» ability to convert sound into brain signals (Molecular Psychiatry, DOI: 10.1038 / MP.2014.8).

As the cochlea's fluid moves, about 15,000 hair cells sitting in it, each tuned to a particular frequency, pick up the motions; the cochlear nerve translates the movements into auditory messages that are sent to the brain.

The scientists injected the USH1G gene into the inner ear using the innocuous AAV8 virus, which enabled them to specifically target the hair cells.

The inner ear comprises the hearing organ or cochlea, together with the five balance organs (the saccule, utricle and three semicircular canals), which contain the sensory cells, or hair cells, that detect mechanical vibrations and convert them into electrical signals.

«This suggested that the negatively charged indole acetic acid hormone molecule is absorbed into the root hair cell together with an excess amount of positive ions,» Hedrich says.

By micro-injecting IAA directly into the root hair, Julian Dindas also demonstrated that an auxin - treated cell does more than send a calcium signal.

While previous vectors have only been able to penetrate the cochlea's inner hair cells, the first Nature Biotechnology study showed that a new synthetic vector, Anc80, safely transferred genes to the hard - to - reach outer hair cells when introduced into the cochlea (see images).

Even more surprising, the team found that the hair cells were created from cells lining the scala media which, according to biological orthodoxy — should not be able to turn into other cells.

Incoming sound waves make the eardrum vibrate, and the eardrum delivers these vibrations using the ossicles to the inner ear where hair cells translate them into electric signals sent to the brain.

The viruses had been engineered to be harmless while also smuggling a gene called Atoh1 into cells lining the scala media — the key chamber of the cochlea, containing the hair cells.

The method, which detects DNA from skin cells, hair, and other cells released into the environment, has already been used to track surface organisms like invasive fish and snakes.

«However, once the dermal papilla cells are put into conventional, two - dimensional tissue culture, they revert to basic skin cells and lose their ability to produce hair follicles.

To deliver the healthy gene, the team inserted it into an engineered virus called adeno - associated virus 1, or AAV1, together with a promoter — a genetic sequence that turns the gene on only in certain sensory cells of the inner ear known as hair cells.

A possible fix arose in 2003, when researchers discovered that certain genes can transform the cells supporting the hair cells into both types of hair cell.

The spiral - shaped organ of Corti, found in the cochlea, houses the sensitive hair cells that convert sound vibrations into nerve impulses.

In order for birds and mammals to hear, hair cells in the cochlea — the auditory portion of the inner ear — vibrate in response to sounds and thereby convert sound into electrical activity.

To see whether one of these genes, called Atoh1, could be used to improve hearing, last year Staecker and colleagues inserted it into a harmless virus and injected that into the cochlea of mice that had had almost all of their hair cells destroyed.

Ligna Li and Robert Hoffman of AntiCancer, a biotechnology company in San Diego, have perfected a technique for delivering DNA into hair follicle cells.

But hair growth depends on the ability of cells in the hair follicles to keep dividing and so producing cells which die and are built into the hair shaft.

The researchers incubate cells with tiny snippets of single - stranded DNA engineered to slip into the cells» outer membranes, covering each cell like the hairs on a tennis ball.

Hendrik is preparing the publication of the most complete woolly mammoth genome yet, and Harvard geneticist George Church's team is already working to introduce specific DNA variants — genes for hair, tusks, subcutaneous fat and cold resistance — into cultured cells from Asian elephants (right).

But when cells undergo stress — anything from heat to starvation or infection — proteins and ribonucleic acid (RNA) molecules can clump into stress granules, which are free of enclosing membranes and often form small globs akin to hair gel suspended in a tub of water.

If cells with functioning KROX20 and SCF are present, they move up from the bulb, interact with pigment - producing melanocyte cells, and grow into pigmented hairs.

A hair of a diode feeds electrical pulses into one side of a single cell; an electrode on the other side records that cell's response.

Healthy hair cells can detect the magnified sounds from a hearing aid and convert them into neural signals.

The study dives into mechanotransduction — how hair cells sense mechanical sound waves, or in this case, water waves, and convert them into brain signals.

When a critter bumps into one of the flytrap's sensitive hairs, the pressure sends an electrical signal racing from cell to cell, priming its jaws to close.

The new neuron is marked red, hair cells that convert sounds into neural signals are green, and hair bundles are blue.

In samples from the same individuals, stem cells that had matured into so - called «progenitor cells» were 10 to 100 times as abundant on hairy patches as on bald ones, suggesting they are the key to hair growth.

As reported in the new study, the researchers were able to postpone the onset of hearing loss and associated hair cell degeneration by about a month, providing enough time to inject normal copies of the Clarin - 1 gene into the ear before the onset of hearing loss to see if the treatment was effective.

So - called hair cells in the inner ear convert sounds into neural signals that are relayed to the brain by spiral ganglion neurons, the study notes.

Electron microscopy revealed that the extra hair cells were divided into inner and outer hair cells, just like the normal ones, and they made the same proteins.

The epithelial stem cells, when implanted into immunocompromised mice, regenerated the different cell types of human skin and hair follicles, and even produced structurally recognizable hair shaft, raising the possibility that they may eventually enable hair regeneration in people.

Human - associated bacteria disperse into and throughout the built environment by three primary mechanisms: (1) direct human contact with indoor surfaces; (2) bioaerosol particle emission from our breath, clothes, skin and hair; and (3) resuspension of indoor dust containing previously shed human skin cells, hair and other bacteria - laden particles.

Hair cells in the cochlea use this gradient to convert the mechanical force of the vibrating eardrum into electrical signals that the brain can understand.

They then converted the iPS cells into epithelial stem cells, normally found at the bulge of hair follicles.

The stem cells in the bulge are multipotent epithelial stem cells, and can become, or differentiate into, all the epithelial cell types in the follicle (including hair follicles, epidermis, and sebaceous glands)(Oshima et al., 2001).

For a rich source of stem cells to be engineered into new blood vessels or skin tissue, clinicians may one day look no further than the hair on their patients» heads, according to new research published earlier this month by University at Buffalo engineers.

The group recently produced data showing that stem cells from human hair follicles also differentiate into contractile smooth muscle cells.

Howard Hughes Medical Institute (HHMI) researchers have isolated stem cells from the skin of mice and shown that they have the power to self - renew and differentiate into skin and functioning hair...

Once identified within the meristem, the hair epidermal cell file was followed into the elongation zone.

Mutations for mammoth hemoglobin, extra hair growth, fat production, down to nuanced climate adaptations such as slightly altered sodium ion channels in cell membranes have already been engineered into fibroblast cell lines.

By turning on a single gene, researchers can prevent skin stem cells from maturing into the three types of adult skin cells — epidermal, sebaceous and hair cells.

If the hair follicle contains melanocyte cells then melanin pigment is incorporated into the cortex cells.

The delicate interplay of two chemical signals coaxes stem cells into becoming hair follicles, according to new research by scientists at the Howard Hughes Medical Institute at The Rockefeller...