«It is rare to get a new technology tested in the laboratory and
moved into human clinical trials so quickly,» said Dranoff, who is also a Professor of Medicine at Harvard Medical School, and Leader of the Dana - Farber / Harvard Cancer Center Program in Cancer Immunology.
Less than a decade after a powerful gene - silencing method — RNA interference, or just RNAi — was discovered, the field's pioneers have not only won the 2006 Nobel Prize in Physiology or Medicine but have also helped launch an entirely new class of
drugs into human clinical trials.
The team plans to move the CAR - T
treatment into human clinical trials, but will build as many safeguards as possible into the trial to minimize risks to people who participate, Monje said.
Aging research may be on the rise, but it does have its own set of unique limitations in terms of how quickly discoveries in the lab
turn into human clinical trials.
Based on these discoveries, Ember plans to advance the BMP7
program into human clinical trials and ultimately hopes to develop an approved drug product that would aid in controlling these metabolic disease conditions that have reached epidemic proportions.
Darrick previously worked at Corixa Corporation, where he led a new tuberculosis
vaccine into human clinical trials and assisted as group leader for analytical biochemistry working on adjuvants and a commercial, radiolabeled mAb for non-Hodgkins lymphoma.
If we take a product that has yet to
go into human clinical trials and we can look at it maybe over a two - year span, that first milestone would be regulatory approval to take it into the first human clinical trials.
Based on data that included those from the fly, AstraZeneca took the
drug into human clinical trials, and in 2011, vandetanib became the first drug approved for late - stage medullary thyroid cancer.
The team is continuing with their experiments, to study the activity of this and other therapeutic ASOs in human breast cancer, with the hope of later moving the
research into human clinical trials.
This study was designed to use readily available agents in an accepted large - animal model of human heart attack with the goal of obtaining evidence that this treatment is ready to be
moved into human clinical trials.»
The recent funding will be used toward building out Kallyope's gut - brain axis platform and getting one of Kallyope's programs near or
into human clinical trials.
While more research is needed to determine whether these approaches could help PD patients, Dr. Greenamyre is optimistic that one or both may ultimately make
it into human clinical trials in an effort to slow or halt the otherwise inevitable progression of PD.